Nuclear receptor subfamily 3 group C member 2 (Q3454531)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

• NR3C2
• mineralocorticoid receptor 1
• mineralocorticoid receptor delta
• mineralocorticoid receptor
• mineralocorticoid receptor 2
• aldosterone receptor
• nuclear receptor subfamily 3, group C, member 2 variant 3
• Receptors, Mineralocorticoid

edit

Language	Label	Description	Also known as
English	Nuclear receptor subfamily 3 group C member 2	mammalian protein found in Homo sapiens	NR3C2 mineralocorticoid receptor 1 mineralocorticoid receptor delta mineralocorticoid receptor mineralocorticoid receptor 2 aldosterone receptor nuclear receptor subfamily 3, group C, member 2 variant 3 Receptors, Mineralocorticoid

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08235

part of

Nuclear hormone receptor-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P08235

Zinc finger, NHR/GATA-type

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P08235

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08235

encoded by

NR3C2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08235

molecular function

sequence-specific DNA binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

DNA binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

DNA-binding transcription factor activity

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

zinc ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

metal ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

steroid hormone receptor activity

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

TAS

steroid binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

protein binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IPI

lipid binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

ISA

ISM

NAS

3 references

retrieved

8 April 2019

stated in

A census of human transcription factors: function, expression and evolution

GOA

curator

Norwegian University of Science and Technology, Systems Biology team

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

NAS

retrieved

8 April 2019

stated in

A census of human transcription factors: function, expression and evolution

GOA

curator

Norwegian University of Science and Technology, Systems Biology team

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

ISM

retrieved

8 April 2019

stated in

GOA

curator

Norwegian University of Science and Technology, Systems Biology team

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

ISA

cell component

cytoplasm

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

endoplasmic reticulum membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

receptor complex

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IDA

endoplasmic reticulum

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

nucleus

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

nucleoplasm

determination method

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IDA

cytosol

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

TAS

biological process

regulation of transcription, DNA-templated

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

transcription, DNA-templated

determination method

IEA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P08235

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08235&geneProductId=UniProtKB:P08235

determination method

IEA

transcription initiation from RNA polymerase II promoter

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

TAS

signal transduction

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

TAS

steroid hormone mediated signaling pathway

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

regulation of transcription by RNA polymerase II

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IEA

positive regulation of NIK/NF-kappaB signaling

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08235

determination method

IMP

physically interacts with

aldosterone

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2872

language of work or name

English

retrieved

17 August 2016

cortisol

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2868

language of work or name

English

retrieved

17 August 2016

deoxycorticosterone

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2871

language of work or name

English

retrieved

17 August 2016

dexamethasone

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2768

language of work or name

English

retrieved

17 August 2016

fludrocortisone

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2873

language of work or name

English

retrieved

17 August 2016

prednisolone

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2866

language of work or name

English

retrieved

17 August 2016

progesterone

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2377

language of work or name

English

retrieved

17 August 2016

drospirenone

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2874

language of work or name

English

retrieved

17 August 2016

finerenone

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8678

language of work or name

English

retrieved

17 August 2016

nimodipine

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2523

language of work or name

English

retrieved

17 August 2016

spironolactone

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2875

language of work or name

English

retrieved

17 August 2016

finerenone

object has role

antagonist

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL2181927

desoxycorticosterone pivalate

object has role

agonist

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL1200592

fludrocortisone acetate

object has role

agonist

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL1201010

desoxycorticosterone acetate

object has role

agonist

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL1200542

Gene Atlas image

PBB GE NR3C2 205259 at fs.png
732 × 530; 12 KB

0 references

has part(s)

nuclear hormone receptor-type zinc finger

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P08235

Nuclear hormone receptor, ligand-binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P08235

Identifiers

MeSH descriptor ID

D018161

subject named as

Receptors, Mineralocorticoid

0 references

MeSH tree code

D12.776.826.750.530

0 references

RefSeq protein ID

NP_000892

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4306

NP_001159576

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4306

XP_011530277

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4306

XP_011530280

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4306

NP_001341748

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4306

UniProt protein ID

P08235

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08235

Ensembl protein ID

ENSP00000421481

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000421481

ENSP00000423510

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000423510

ENSP00000341390

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000341390

ENSP00000343907

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000343907

ENSP00000350815

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000350815

ENSP00000486719

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000486719

Freebase ID

/m/0d_dmr

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

189135053

0 references

OpenAlex ID

C189135053

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1Y9R

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

1YA3

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

2A3I

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

2AA2

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

2AA5

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

2AA6

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

2AA7

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

2AAX

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

2AB2

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

2ABI

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

2OAX

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

3VHU

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

3VHV

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

3WFF

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

3WFG

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

4PF3

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

4TNT

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

4UDB

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

4UDA

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

5HCV

1 reference

stated in

UniProt

UniProt protein ID

P08235

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(13 entries)

edit

• cywiki NR3C2
• dewiki Mineralokortikoidrezeptor
• enwiki Mineralocorticoid receptor
• eswiki Receptor de mineralcorticoides
• frwiki Récepteur des minéralocorticoïdes
• jawiki 鉱質コルチコイド受容体
• mswiki Reseptor mineralokortikoid
• ptwiki Receptor mineralocorticoide
• shwiki Mineralokortikoidni receptor
• srwiki Mineralokortikoidni receptor
• svwiki Mineralokortikoidreceptor
• ttwiki NR3C2
• ukwiki NR3C2

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q3454531&oldid=2061751790"