Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies (Q34548815)

3 August 2017

title

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies (English)

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3 August 2017

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34

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Hanna Axelsson

15

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Nikolas Herold

Nikolas Herold

1

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Sean G Rudd

Sean G Rudd

2

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Bianca Tesi

Bianca Tesi

16

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Katja Pokrovskaja Tamm

Katja Pokrovskaja Tamm

José Manuel Calderón-Montaño

25

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José M Calderón-Montaño

11

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Thomas Lundbäck

Thomas Lundbäck

30

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Per Kogner

Per Kogner

31

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Thomas Helleday

Thomas Helleday

33

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Jan-Inge Henter

Jan-Inge Henter

32

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Ann-Sofie Jemth

Ann-Sofie Jemth

13

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Andreas Höglund

18

Andreas Höglund

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3 August 2017

Ulrika Warpman Berglund

26

Ulrika Warpman-Berglund

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3 August 2017

20

Elisée Wiita

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3 August 2017

6

Cynthia B J Paulin

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3 August 2017

8

Anna Hagenkort

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3 August 2017

17

Nicholas C K Valerie

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3 August 2017

9

Juliane Kutzner

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3 August 2017

Linda Ljungblad

3

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3 August 2017

Kumar Sanjiv

4

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Ida Hed Myrberg

5

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3 August 2017

Yaser Heshmati

7

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3 August 2017

Brent D G Page

10

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3 August 2017

Olga Loseva

12

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3 August 2017

Lorenzo Bulli

14

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3 August 2017

Julia Bladh

19

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3 August 2017

Mikael Sundin

21

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3 August 2017

Michael Uhlin

22

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3 August 2017

Georgios Rassidakis

23

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3 August 2017

Mats Heyman

24

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Julian Walfridsson

27

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Sören Lehmann

28

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3 August 2017

Dan Grandér

29

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3 August 2017

language of work or name

English

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publication date

9 January 2017

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3 August 2017

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3 August 2017

volume

23

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3 August 2017

issue

2

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3 August 2017

page(s)

256-263

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Important milestones in acute leukemia in 2013.

3 August 2017

cites work

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Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells

21 January 2018

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A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity.

21 January 2018

1 reference

Potential mechanisms of resistance to cytarabine in AML patients

21 January 2018

1 reference

Pediatric AML: From Biology to Clinical Management

21 January 2018

1 reference

How I treat the older patient with acute myeloid leukemia

21 January 2018

1 reference

Drug resistance in childhood acute myeloid leukemia

21 January 2018

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Substrate cycles and drug resistance to 1-beta-D-arabinofuranosylcytosine (araC).

21 January 2018

1 reference

Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia

21 January 2018

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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

21 January 2018

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Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells

21 January 2018

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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

21 January 2018

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Structural basis of cellular dNTP regulation by SAMHD1.

21 January 2018

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A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1

21 January 2018

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Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

21 January 2018

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Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

21 January 2018

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Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation

21 January 2018

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Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.

21 January 2018

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Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit

21 January 2018

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Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs

21 January 2018

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

21 January 2018

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Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

21 January 2018

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Downregulation of SAMHD1 expression correlates with promoter DNA methylation in Sézary syndrome patients.

21 January 2018

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SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation

21 January 2018

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MicroRNA-181 expression regulates specific post-transcriptional level of SAMHD1 expression in vitro

21 January 2018

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The pathological role and prognostic impact of miR-181 in acute myeloid leukemia

21 January 2018

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miR-181a sensitizes resistant leukaemia HL-60/Ara-C cells to Ara-C by inducing apoptosis

21 January 2018

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Anthracycline dose intensification in acute myeloid leukemia

21 January 2018

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Genetic factors influencing cytarabine therapy

21 January 2018

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SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

21 January 2018

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Aggressive CD8(+) epidermotropic cutaneous T-cell lymphoma associated with homozygous mutation in SAMHD1.

21 January 2018

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Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

21 January 2018

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A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase

21 January 2018

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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

21 January 2018

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A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanisms

21 January 2018

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Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection

21 January 2018

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Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti- and retroviral vectors

21 January 2018

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Genome-scale CRISPR-Cas9 knockout screening in human cells

21 January 2018

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Improved vectors and genome-wide libraries for CRISPR screening

21 January 2018

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HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency

21 January 2018

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The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions

21 January 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

21 January 2018

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Cellular pharmacology and optimal therapeutic concentrations of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in leukemic blasts during treatment of refractory leukemia with high-dose 1-beta-D-arabinofuranosylcytosine

21 January 2018

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12 December 2020

Influence of clofarabine on transcriptional activity of PTEN, APC, RARB2, ZAP70 genes in K562 cells

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12 December 2020

Uptake and phosphorylation of cytosine arabinoside by normal and leukemic human blood cells in vitro

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12 December 2020

Prognostic value of in vitro uptake and retention of cytosine arabinoside in acute myelogenous leukemia.

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12 December 2020

Relationships among Ara-CTP pools, formation of (Ara-C)DNA, and cytotoxicity of human leukemic cells

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12 December 2020

Rationales for a pharmacologically optimized treatment of acute nonlymphocytic leukemia with cytosine arabinoside.

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12 December 2020

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria.

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12 December 2020

Variables predicting response to high dose cytosine arabinoside therapy in patients with refractory acute leukemia

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12 December 2020

Identifiers

DOI

10.1038/NM.4265

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3 August 2017

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