Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin (Q34553588)

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English	Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1 reference

based on heuristic

inferred from title

author name string

Isbrucker RA

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

Burdock GA

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

language of work or name

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publication date

1 August 2006

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Europe PubMed Central

PubMed publication ID

3 August 2017

Regulatory Toxicology and Pharmacology

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Europe PubMed Central

PubMed publication ID

3 August 2017

46

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Europe PubMed Central

PubMed publication ID

3 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

167-192

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Effects of glycyrrhizin and glycyrrhetinic acid on growth and melanogenesis in cultured B16 melanoma cells

1 reference

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Interferon Induction by Glycyrrhizin and Glycyrrhetinic Acid in Mice

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Metabolism of glycyrrhetic acid by rat liver microsomes--III. Male-specific glycyrrhetinate dehydrogenase

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Metabolism of glycyrrhetic acid by rat liver microsomes: glycyrrhetinate dehydrogenase

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Intestinal bacterial hydrolysis is indispensable to absorption of 18 beta-glycyrrhetic acid after oral administration of glycyrrhizin in rats

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Inhibitory effects of glycyrrhetic acid derivatives on 11 beta- and 3 alpha-hydroxysteroid dehydrogenases of rat liver

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Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats

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Reduction of serum testosterone in men by licorice

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Licorice consumption and serum testosterone in healthy man.

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Affinity of liquorice derivatives for mineralocorticoid and glucocorticoid receptors

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Mineralocorticoid effector mechanism of liquorice derivatives in human mononuclear leukocytes

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Aspirin-induced gastric mucosal damage in rats: Cimetidine and degly-cyhrrhizinated liquorice together give greater protection than low doses of either drug alone

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Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo

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Effects of prolonged ingestion of graded doses of licorice by healthy volunteers

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In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination

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Interaction of licorice on glycyrrhizin pharmacokinetics

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Toxicological assessment of liquorice: biliary excretion in rats

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Effects of liquorice and its derivatives on salt and water metabolism

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Toxicologic evaluation of licorice extract as a cigarette ingredient

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Inhibition of N-acetyltransferase activity and DNA-2-aminofluorene adducts by glycyrrhizic acid in human colon tumour cells

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Effect of low dosage of carbenoxolone sodium on gastric ulcer healing and acid secretion

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Metabolic Studies of Deglycyrrhizinised Liquorice in Two Patients with Gastric Ulcer

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Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses

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Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer

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Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects

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Licorice Raises Urinary Cortisol in Man*

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Effects of licorice on plasma atrial natriuretic peptide in healthy volunteers

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An immunotoxicity assessment of food flavouring ingredients

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Production of experimental hypertension and cardiovascularrenal lesions with licorice and ammoniated glycyrrhizin

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Profound difference of metabolic pharmacokinetics between pure glycyrrhizin and glycyrrhizin in licorice decoction

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11beta-hydroxysteroid dehydrogenase type 1: a new regulator of fetal lung maturation

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Anti-herpes virus type 1 activity of oleanane-type triterpenoids

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Antimutagenic effect of fruit and vegetable ethanolic extracts against N-nitrosamines evaluated by the Ames test

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Glycyrrhizin binding site on human serum albumin

1 reference

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Binding of glycyrrhizin to human serum and human serum albumin

1 reference

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Effects of FM100, a fraction of licorice root, on serum gastrin concentration in rats and dogs

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The Metabolism of Carbenoxolone in the Rat

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Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression

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Liquorice consumption and salivary testosterone concentrations

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Biotransformation of glycyrrhizin by human intestinal bacteria and its relation to biological activities

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Biotransformation of glycyrrhizin to 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide by Streptococcus LJ-22, a human intestinal bacterium

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Mechanism of antihepatotoxic activity of glycyrrhizin. I: Effect on free radical generation and lipid peroxidation

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Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro

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Tumorigenicity study of disodium glycyrrhizinate administered orally to mice

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Glycyrrhizin-induced inhibition of the pituitary-adrenal stress response

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The effects of the licorice derivative, glycyrrhetinic acid, on hepatic 3 alpha- and 3 beta-hydroxysteroid dehydrogenases and 5 alpha- and 5 beta-reductase pathways of metabolism of aldosterone in male rats.

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The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers

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Teratogenicity study of ammonium glycyrrhizinate in the Sprague-Dawley rat

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Antithrombotic effect of Glycyrrhizin, a plant-derived thrombin inhibitor

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A liquorice extract with deoxycortone-like action

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Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies

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Licorice, tobacco chewing, and hypertension

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Effect of glycyrrhizin on hepatic lysosomal systems

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Enzyme leakage due to change of membrane permeability of primary cultured rat hepatocytes treated with various hepatotoxins and its prevention by glycyrrhizin

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Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases

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A human physiologically-based model for glycyrrhzic acid, a compound subject to presystemic metabolism and enterohepatic cycling.

1 reference

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The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling

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Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling.

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Clinical and pharmacological investigations on extract of licorice

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Correlation between high intake of glycyrrhizin and myolysis of the papillary muscles: an experimental in vivo study

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Effects of glycyrrhizic acid on right atrial pressure and pulmonary vasculature in rats

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Effect of glycyrrhizin, an active component of licorice roots, on HIV replication in cultures of peripheral blood mononuclear cells from HIV-seropositive patients

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Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice.

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Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age

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Preterm birth and licorice consumption during pregnancy

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Birth outcome in relation to licorice consumption during pregnancy

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Antidiabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice

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Inhibition by plant herb extracts of steroid bindings in uterus, liver and serum of the rabbit

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Possible mechanism of steroid action of the plant herb extracts glycyrrhizin, glycyrrhetinic acid, and paeoniflorin: inhibition by plant herb extracts of steroid protein binding in the rabbit

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Estrogen-like activity of glabrene and other constituents isolated from licorice root

1 reference

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Glycyrrhizic acid suppresses type 2 11 beta-hydroxysteroid dehydrogenase expression in vivo

1 reference

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Inhibition of mutagenicity by glycyrrhiza extract and glycyrrhizin

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1 reference

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Intravenous glycyrrhizin for the treatment of chronic hepatitis C: A double‐blind, randomized, placebo‐controlled phase I/II trial

1 reference

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Pharmacokinetics of intravenous glycyrrhizin after single and multiple doses in patients with chronic hepatitis C infection

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Glycyrrhizin-induced reduction of ALT in European patients with chronic hepatitis C.

1 reference

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Natural killer activity in patients with chronic hepatitis treated with OK432, interferon, adenine arabinoside and glycyrrhizin

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Licorice and cancer

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Gastrointestinal absorption characteristics of glycyrrhizin from glycyrrhiza extract

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Uncoupling of oxidative phosphorylation by glycyrrhetic acid, fusidic acid and some related triterpenoid acids

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Administration-route dependency of absorption of glycyrrhizin in rats: intraperitoneal administration dramatically enhanced bioavailability

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Inhibition of mutagenicity in Salmonella typhimurium by Glycyrrhiza glabra extract, glycyrrhizinic acid, 18 alpha- and 18 beta-glycyrrhetinic acids.

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Randomized clinical trial with two doses (100 and 40 ml) of Stronger Neo-Minophagen C in Chinese patients with chronic hepatitis B

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Effect of liquorice and glycyrrhizin on rat liver carcinogen metabolizing enzymes

1 reference

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based on heuristic

inferred from DOI database lookup

Combination Theram with Transfer Factor and High Dose Strongei Neo-Minophagen C in Chronic Hepatitis B in Children (HBe Ag Positive)

1 reference

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based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.YRTPH.2006.06.002

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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