A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis (Q34553682)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20814896%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis (English)

1 reference

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13 February 2020

main subject

phase I clinical trial

0 references

phase II clinical trial

0 references

1 reference

10

1 reference

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13 February 2020

Wolfgang Stremmel

14

1 reference

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13 February 2020

Antonello Pietrangelo

18

1 reference

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13 February 2020

5

Herbert L Bonkovsky

1 reference

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13 February 2020

author name string

Pradyumna Phatak

1

1 reference

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13 February 2020

Pierre Brissot

2

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13 February 2020

Mark Wurster

3

1 reference

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13 February 2020

Paul C Adams

4

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13 February 2020

John Gross

6

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13 February 2020

Gordon D McLaren

8

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13 February 2020

Claus Niederau

9

1 reference

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13 February 2020

Lawrie W Powell

11

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13 February 2020

Mark W Russo

12

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13 February 2020

Ulrich Stoelzel

13

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13 February 2020

Louis Griffel

15

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13 February 2020

Nicola Lynch

16

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13 February 2020

Yiyun Zhang

17

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13 February 2020

Peter Malfertheiner

7

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13 February 2020

language of work or name

English

0 references

publication date

1 November 2010

1 reference

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13 February 2020

1 reference

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13 February 2020

volume

52

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13 February 2020

page(s)

1671-1779

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13 February 2020

issue

5

1 reference

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Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias.

13 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

The natural history of untreated HFE-related hemochromatosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Iron-overload-related disease in HFE hereditary hemochromatosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Iron chelation beyond transfusion iron overload.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

The myths and realities of hemochromatosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Phase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in pediatric patients with beta-thalassemia major

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Genetics of haemochromatosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Cancer phase I clinical trials: efficient dose escalation with overdose control.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Serum Ferritin Level Predicts Advanced Hepatic Fibrosis among U.S. Patients with Phenotypic Hemochromatosis

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FHEP.23879

Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Critical aspects of the Bayesian approach to phase I cancer trials.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Intramuscular deferoxamine in hereditary hemochromatosis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Hemochromatosis mutations in the general population: iron overload progression rate

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Evolution of untreated hereditary hemochromatosis in the Busselton population: a 17-year study.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Effective treatment of hereditary haemochromatosis with desferrioxamine in selected cases

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH)

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034044

Patient compliance with phlebotomy therapy for iron overload associated with hemochromatosis

9 December 2018

1 reference

12 December 2020

Long-term survival in patients with hereditary hemochromatosis

1 reference

12 December 2020

Reversible severe hereditary hemochromatotic cardiomyopathy

1 reference

12 December 2020

Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload

1 reference

12 December 2020

Safety and efficacy of subcutaneous bolus injection of deferoxamine in adult patients with iron overload

1 reference

12 December 2020

Identifiers

DOI

10.1002/HEP.23879

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20814896%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20814896%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20814896%20AND%20SRC:MED&resulttype=core&format=json