Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic (Q34559481)

3 August 2017

title

Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic (English)

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3 August 2017

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John L Neumeyer

9

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Severo Salvadori

object named as

Severo Salvadori

2

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author name string

Gianfranco Balboni

1

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3 August 2017

Ewa D Marczak

3

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3 August 2017

Brian I Knapp

4

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3 August 2017

Jean M Bidlack

5

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3 August 2017

Lawrence H Lazarus

6

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3 August 2017

Xuemei Peng

7

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3 August 2017

Yu Gui Si

8

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3 August 2017

publication date

8 December 2010

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European Journal of Medicinal Chemistry

3 August 2017

published in

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3 August 2017

volume

46

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3 August 2017

issue

2

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3 August 2017

page(s)

799-803

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Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid Pharmacophore

3 August 2017

cites work

1 reference

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7 July 2018

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Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization

7 July 2018

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Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors

7 July 2018

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7 July 2018

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Opioid-receptor-heteromer-specific trafficking and pharmacology

7 July 2018

1 reference

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Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands

7 July 2018

1 reference

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Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

7 July 2018

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Bi- or multifunctional opioid peptide drugs

7 July 2018

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Design of multivalent ligand targeting G-protein-coupled receptors

7 July 2018

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In vivo trafficking of endogenous opioid receptors

7 July 2018

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Multiple ligands in opioid research

7 July 2018

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The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

7 July 2018

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A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic

7 July 2018

1 reference

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Pharmacological Properties of Bivalent Ligands Containing Butorphan Linked to Nalbuphine, Naltrexone, and Naloxone at μ, δ, and κ Opioid Receptors

7 July 2018

1 reference

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Kappa receptor bivalent ligands.

7 July 2018

1 reference

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New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores

7 July 2018

1 reference

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Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics

7 July 2018

1 reference

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Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.

7 July 2018

1 reference

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Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035428

Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity

7 July 2018

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035428

Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035428

Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035428

Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035428

Chronic morphine treatment increases the number, but decreases the affinity of [3H]-U69,593 binding sites in the rat heart

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21216504

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.EJMECH.2010.12.001

1 reference

3 August 2017

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3 August 2017

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