PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation (Q34560212)

3 August 2017

PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation (English)

1 reference

3 August 2017

1 reference

Michael Holinstat

1

1 reference

3 August 2017

Bryan Voss

2

1 reference

3 August 2017

Matthew L Bilodeau

3

1 reference

3 August 2017

Joseph N McLaughlin

4

1 reference

3 August 2017

John Cleator

5

1 reference

3 August 2017

Heidi E Hamm

6

1 reference

3 August 2017

language of work or name

English

0 references

publication date

12 July 2006

1 reference

Journal of Biological Chemistry

3 August 2017

1 reference

3 August 2017

281

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3 August 2017

36

1 reference

3 August 2017

26665-26674

1 reference

The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3

3 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Fibrinogen and fibrin structure and functions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

The multifunctional protein C system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKCdelta in platelets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Rap1b is required for normal platelet function and hemostasis in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Glycoprotein IIb/IIIa receptor antagonists and risk of bleeding: a single-center experience in 1020 patients

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Platelet secretory mechanisms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Pharmacodynamic profile of antiplatelet agents: marked differences between single versus costimulation with platelet activators

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Protease-activated receptors: contribution to physiology and disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Central role of the P2Y12 receptor in platelet activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Role of antiplatelet drugs in the prevention of cardiovascular events

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Thrombin and platelet activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Proteinase-activated receptors.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Thrombin signalling and protease-activated receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Sequential regulation of the small GTPase Rap1 in human platelets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

How the protease thrombin talks to cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Vascular-bed--specific hemostasis and hypercoagulable states

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

A dual thrombin receptor system for platelet activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Cloning and characterization of human protease-activated receptor 4

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

The many faces of G protein signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

G protein beta gamma subunits.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Protease-activated receptor 3 is a second thrombin receptor in humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Rapid Ca2+-mediated activation of Rap1 in human platelets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

The pathogenesis of coronary artery disease and the acute coronary syndromes (2).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035573

Bivalirudin in PCI: an overview of the REPLACE-2 trial

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602174200

Measurement of GTP-bound Ras-like GTPases by activation-specific probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602174200

Activation of Rap1B by G(i) family members in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602174200

Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602174200

Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602174200

Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602174200

Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood Platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602174200

Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets

21 January 2018

1 reference

12 December 2020

Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk

1 reference

12 December 2020

Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro

1 reference

12 December 2020

Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry

1 reference

12 December 2020

Pathophysiology of platelet thrombin receptors

1 reference

12 December 2020

Cloning of PAR3 cDNA from human platelets, and human erythroleukemic and human promonocytic cell lines

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M602174200

1 reference

3 August 2017

1 reference

3 August 2017

1 reference