Structure of the insulin receptor ectodomain reveals a folded-over conformation (Q34564193)

3 August 2017

Structure of the insulin receptor ectodomain reveals a folded-over conformation (English)

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3 August 2017

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Neil M McKern

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3 August 2017

Michael C Lawrence

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Victor A Streltsov

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Mei-Zhen Lou

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Timothy E Adams

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George O Lovrecz

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Thomas C Elleman

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Kim M Richards

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John D Bentley

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Patricia A Pilling

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Peter A Hoyne

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Kellie A Cartledge

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Tam M Pham

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Jennifer L Lewis

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Sonia E Sankovich

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Violet Stoichevska

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Elizabeth Da Silva

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Christine P Robinson

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Maurice J Frenkel

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Lindsay G Sparrow

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Ross T Fernley

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V Chandana Epa

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Colin W Ward

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3 August 2017

language of work or name

English

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publication date

6 September 2006

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443

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7108

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218-221

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https://scigraph.springernature.com/pub.10.1038/nature05106

3 August 2017

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The insulin receptor isoform exon 11- (IR-A) in cancer and other diseases: a review.

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Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

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Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocks

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Structural biology of insulin and IGF1 receptors: implications for drug design

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Mechanism of transmembrane signaling: insulin binding and the insulin receptor

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The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity

21 January 2018

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Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

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The insulin receptor: from protein sequence to structure.

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An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

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Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy.

21 January 2018

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Hormone-triggered conformational changes within the insulin-receptor ectodomain: requirement for transmembrane anchors

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Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies

21 January 2018

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The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

21 January 2018

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Insulin and its receptor: structure, function and evolution

21 January 2018

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A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies

21 January 2018

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High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper

21 January 2018

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The disulfide bonds in the C-terminal domains of the human insulin receptor ectodomain

21 January 2018

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7 January 2021

Optimizing long intrinsic disorder predictors with protein evolutionary information

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https://api.crossref.org/works/10.1038%2FNATURE05106

7 January 2021

Single-molecule imaging of human insulin receptor ectodomain and its Fab complexes

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https://api.crossref.org/works/10.1038%2FNATURE05106

7 January 2021

Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit

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https://api.crossref.org/works/10.1038%2FNATURE05106

7 January 2021

A model for insulin binding to the insulin receptor

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https://api.crossref.org/works/10.1038%2FNATURE05106

7 January 2021

Identifiers

DOI

10.1038/NATURE05106

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Dimensions Publication ID

3 August 2017

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