A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells (Q34564351)

3 August 2017

title

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells (English)

1 reference

3 August 2017

10

Pavel Savitsky

0 references

Peter J McHugh

Peter J McHugh

12

0 references

Opher Gileadi

Opher Gileadi

16

0 references

Ajit Jadhav

Ajit Jadhav

15

0 references

Anton Simeonov

18

Anton Simeonov

1 reference

3 August 2017

Giang Huong Nguyen

1

1 reference

3 August 2017

Thomas S Dexheimer

2

1 reference

3 August 2017

Andrew S Rosenthal

3

1 reference

3 August 2017

Wai Kit Chu

4

1 reference

3 August 2017

Dharmendra Kumar Singh

5

1 reference

3 August 2017

Georgina Mosedale

6

1 reference

3 August 2017

Csanád Z Bachrati

7

1 reference

3 August 2017

Lena Schultz

8

1 reference

3 August 2017

Masaaki Sakurai

9

1 reference

3 August 2017

Pavel Savitsky

10

1 reference

3 August 2017

Mika Abu

11

1 reference

3 August 2017

Vilhelm A Bohr

13

1 reference

3 August 2017

Curtis C Harris

14

1 reference

3 August 2017

David J Maloney

17

1 reference

3 August 2017

Ian D Hickson

19

1 reference

3 August 2017

publication date

1 January 2013

1 reference

3 August 2017

published in

Chemistry and Biology

1 reference

3 August 2017

volume

20

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3 August 2017

issue

1

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3 August 2017

page(s)

55-62

1 reference

describes a project that uses

3 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3558928/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

RecQ helicases: multifunctional genome caretakers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Structure of the human RECQ1 helicase reveals a putative strand-separation pin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

The HRDC domain of BLM is required for the dissolution of double Holliday junctions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

RecQ helicases: suppressors of tumorigenesis and premature aging.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Unwinding the 'Gordian knot' of helicase action.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Binding and melting of D-loops by the Bloom syndrome helicase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

The Bloom's syndrome gene product interacts with topoisomerase III

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

Bloom's syndrome. XX. The first 100 cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

The Bloom's syndrome gene product is homologous to RecQ helicases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3558928

SGS1 is required for telomere elongation in the absence of telomerase

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23352139

12 December 2020

inferred from PubMed ID database lookup

The Bloom's syndrome helicase unwinds G4 DNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23352139

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CHEMBIOL.2012.10.016

1 reference

release_dizku4rzfzh43hx4huy35d32di

3 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/dizku4rzfzh43hx4huy35d32di

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3558928

1 reference

3 August 2017

1 reference