Structural basis for macrolactonization by the pikromycin thioesterase (Q34565714)

3 August 2017

title

Structural basis for macrolactonization by the pikromycin thioesterase (English)

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3 August 2017

David L Akey

1

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3 August 2017

Jeffrey D Kittendorf

2

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3 August 2017

John W Giraldes

3

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3 August 2017

Robert A Fecik

4

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3 August 2017

David H Sherman

5

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3 August 2017

Janet L Smith

6

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3 August 2017

publication date

10 September 2006

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3 August 2017

published in

Nature Chemical Biology

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3 August 2017

volume

2

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3 August 2017

issue

10

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3 August 2017

page(s)

537-542

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Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products

3 August 2017

cites work

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Alternative modular polyketide synthase expression controls macrolactone structure

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Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase

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Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase

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7 January 2021

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

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Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases

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Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

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7 January 2021

Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin

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7 January 2021

Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase

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Linear aglycones are the substrates for glycosyltransferase DesVII in methymycin biosynthesis: analysis and implications

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Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli

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7 January 2021

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Identifiers

DOI

10.1038/NCHEMBIO824

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3 August 2017

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