Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a review (Q34568687)

3 August 2017

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title

Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a review (English)

1 reference

3 August 2017

Karen L Houseknecht

1

1 reference

PubMed ID

11900961

3 August 2017

Bridget M Cole

series ordinal

2

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PubMed ID

11900961

3 August 2017

Pamela J Steele

series ordinal

3

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3 August 2017

1 March 2002

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3 August 2017

23

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Domestic Animal Endocrinology

inferred from page(s)

published in

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3 August 2017

22

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3 August 2017

1

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3 August 2017

1-23

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The nuclear receptor superfamily: the second decade

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Interdomain communication regulating ligand binding by PPAR-gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The PPARs: from orphan receptors to drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The pleiotropic functions of peroxisome proliferator-activated receptor gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

PPAR gamma is required for placental, cardiac, and adipose tissue development

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

A one-vial method for routine extraction and quantification of free fatty acids in blood and tissue by HPLC

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Cyclopentenone prostaglandins: new insights on biological activities and cellular targets

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The carboxyl-terminal fragment of alpha1-antitrypsin is present in atherosclerotic plaques and regulates inflammatory transcription factors in primary human monocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Regulation of adipose cell number in man

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Molecular regulation of adipogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Peroxisome proliferator activated receptor gamma, CCAAT/enhancer-binding protein alpha, and cell cycle status regulate the commitment to adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

PPARgamma, the ultimate thrifty gene

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The interaction between vitamin A and thiazolidinedione on bovine adipocyte differentiation in primary culture

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Effects of lipid-related factors on adipocyte differentiation of bovine stromal-vascular cells in primary culture

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Enhancing effect of troglitazone on porcine adipocyte differentiation in primary culture: a comparison with dexamethasone

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Characterisation of porcine peroxisome proliferator-activated receptors gamma 1 and gamma 2: detection of breed and age differences in gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Expression and cDNA cloning of porcine peroxisome proliferator-activated receptor gamma (PPARgamma).

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Characterisation of bovine peroxisome proliferator-activated receptors gamma 1 and gamma 2: genetic mapping and differential expression of the two isoforms.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Rapid communication: physical and genetic mapping of the Peroxisome Proliferator Activated Receptor gamma (PPAR-gamma) gene to porcine chromosome 13.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Developmental and nutritional changes of ob and PPAR gamma 2 gene expression in rat white adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Nutritional deprivation reduces the transcripts for transcription factors and adipocyte-characteristic proteins in porcine adipocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Regulation of PPARgamma but not obese gene expression by dietary fat supplementation

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Dietary regulation of glucose transporter gene expression: tissue specific effects in adipose cells and muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Regulation of adipocyte gene expression by polyunsaturated fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Peroxisome proliferator-activated receptors: a critical link among fatty acids, gene expression and carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Effects of modified tall oil versus a commercial source of conjugated linoleic acid and increasing levels of modified tall oil on growth performance and carcass characteristics of growing-finishing pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The hormone resistin links obesity to diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

A family of tissue-specific resistin-like molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

1 reference

7 January 2021

The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator--activated receptor-gamma2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Two Polymorphisms in the Peroxisome Proliferator-Activated Receptor- Gene Are Associated with Severe Overweight among Obese Women

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Evidence for gene-nutrient interaction at the PPARgamma locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Peroxisome proliferator-activated receptor gamma1 expression in porcine white blood cells: dynamic regulation with acute endotoxemia

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) alpha and gamma and retinoid Z receptor in cartilage. PPARgamma activation modulates the effects of interleukin-1beta on rat chondrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Peroxisome proliferator-activated receptors in tumorigenesis: targets of tumour promotion and treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Troglitazone and related compounds: therapeutic potential beyond diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Terminal differentiation of human breast cancer through PPAR gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Differentiation and reversal of malignant changes in colon cancer through PPARgamma

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Activation of PPARgamma inhibits cell growth and induces apoptosis in human gastric cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Activators of the nuclear receptor PPARgamma enhance colon polyp formation

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS0739-7240%2801%2900117-5

7 January 2021

10.1016/S0739-7240(01)00117-5

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11900961