The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. (Q34568855)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974671%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells (English)

1 reference

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14 January 2020

1 reference

4

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14 January 2020

Paul M. Thomas

5

1 reference

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14 January 2020

author name string

Eva Martinez-Garcia

1

1 reference

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14 January 2020

Relja Popovic

2

1 reference

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14 January 2020

Dong-Joon Min

3

1 reference

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14 January 2020

Leonid Zamdborg

6

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14 January 2020

Aaron Heffner

7

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14 January 2020

Christine Will

8

1 reference

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14 January 2020

Laurence Lamy

9

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14 January 2020

Louis M Staudt

10

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14 January 2020

David L Levens

11

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14 January 2020

Neil L Kelleher

12

1 reference

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14 January 2020

Jonathan D Licht

13

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14 January 2020

language of work or name

English

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publication date

25 October 2010

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14 January 2020

number of pages

10

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inferred from page(s)

published in

Blood

1 reference

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14 January 2020

volume

117

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14 January 2020

page(s)

211-220

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14 January 2020

issue

1

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Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma.

14 January 2020

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7 July 2018

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G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

7 July 2018

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7 July 2018

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Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5.

7 July 2018

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Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity

7 July 2018

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The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

7 July 2018

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MLL translocations, histone modifications and leukaemia stem-cell development

7 July 2018

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The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

7 July 2018

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Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma.

7 July 2018

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7 July 2018

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7 July 2018

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The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

7 July 2018

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Ten years and counting: so what do we know about t(4;14)(p16;q32) multiple myeloma.

7 July 2018

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ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

7 July 2018

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Myc influences global chromatin structure.

7 July 2018

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7 July 2018

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Molecular pathogenesis and a consequent classification of multiple myeloma

7 July 2018

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Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes

7 July 2018

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7 July 2018

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Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

7 July 2018

1 reference

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7 July 2018

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Heterogeneous pattern of chromosomal breakpoints involving the MYC locus in multiple myeloma.

7 July 2018

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Role of histone H3 lysine 27 methylation in X inactivation

7 July 2018

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A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript

7 July 2018

1 reference

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Translating the Histone Code

7 July 2018

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NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines

7 July 2018

1 reference

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A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037745

JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cells

7 July 2018

1 reference

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The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037745

WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037745

Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037745

SET domain proteins modulate chromatin domains in eu- and heterochromatin.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037745

Chromosomal subunits in active genes have an altered conformation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037745

Deregulation of H3K27 methylation in cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037745

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

27 October 2018

1 reference

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NUP98–NSD1 fusion by insertion in acute myeloblastic leukemia

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037745

Pervasive combinatorial modification of histone H3 in human cells

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20974671

12 December 2020

inferred from PubMed ID database lookup

MMSET is overexpressed in cancers: link with tumor aggressiveness

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20974671

12 December 2020

inferred from PubMed ID database lookup

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20974671

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1182/BLOOD-2010-07-298349

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974671%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974671%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference