Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma (Q34568941)

3 August 2017

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title

Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma (English)

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3 August 2017

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Jeremy R Graff

1

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3 August 2017

language of work or name

English

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publication date

1 February 2002

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Expert Opinion on Therapeutic Targets

3 August 2017

published in

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3 August 2017

volume

6

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3 August 2017

issue

1

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3 August 2017

page(s)

103-113

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The role of vitamin D in prostate cancer

3 August 2017

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Cyclin D1 expression in human prostate carcinoma cell lines and primary tumors

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Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

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Pten is essential for embryonic development and tumour suppression

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

21 January 2018

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

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Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis

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PI3-K/AKT regulation of NF-kappaB signaling events in suppression of TNF-induced apoptosis

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

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Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

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Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

21 January 2018

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

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Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

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Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

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Association of p27Kip1 levels with recurrence and survival in patients with stage C prostate carcinoma

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

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Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

21 January 2018

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Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

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Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state

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Regulation of translation initiation by FRAP/mTOR

21 January 2018

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

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Synthesis of the translational apparatus is regulated at the translational level

21 January 2018

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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

21 January 2018

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Expression of the insulin-like growth factor system and cancer progression in hormone-treated prostate cancer patients.

21 January 2018

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Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

21 January 2018

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Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

21 January 2018

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Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

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Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

21 January 2018

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Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity

21 January 2018

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

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Akt is activated in response to an apoptotic signal.

21 January 2018

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Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

21 January 2018

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Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

21 January 2018

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21 January 2018

Identifiers

DOI

10.1517/14728222.6.1.103

1 reference

3 August 2017

1 reference