Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer (Q34571777)

3 August 2017

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title

Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer (English)

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3 August 2017

S R Johnston

1

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3 August 2017

publication date

1 January 2001

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Lancet Oncology Commission

3 August 2017

published in

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3 August 2017

volume

2

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3 August 2017

issue

1

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3 August 2017

page(s)

18-26

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

3 August 2017

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7 January 2021

Activators and effectors of ras p21 proteins

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

1 reference

7 January 2021

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

The activation of phosphatidylinositol 3-kinase by Ras

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Ras biology in atomic detail

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Isolation of a transforming sequence from a human bladder carcinoma cell line

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Function and regulation of ras.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

The extracellular matrix as a cell survival factor

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Disruption of epithelial cell-matrix interactions induces apoptosis

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant c-H-ras oncogene expression

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Aberrant function of the Ras signal transduction pathway in human breast cancer

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Proliferation of human malignant astrocytomas is dependent on Ras activation

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Protein prenyltransferases

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Ras farnesyltransferase: a new therapeutic target

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

Radiosensitization and apoptosis

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https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900191-1

7 January 2021

10.1016/S1470-2045(00)00191-1

Identifiers

DOI

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3 August 2017

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