Regulation of lymphocyte proliferation and death by FLIP. (Q34572136)

3 August 2017

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title

Regulation of lymphocyte proliferation and death by FLIP. (English)

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3 August 2017

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2

Tschopp J

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3 August 2017

Thome M

1

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3 August 2017

1 October 2001

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Nature Reviews Immunology

3 August 2017

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3 August 2017

1

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3 August 2017

1

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3 August 2017

50-58

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

3 August 2017

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7 January 2021

More than one way to die: apoptosis, necrosis and reactive oxygen damage

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7 January 2021

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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7 January 2021

Caspase structure, proteolytic substrates, and function during apoptotic cell death

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7 January 2021

Apoptosis control by death and decoy receptors

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7 January 2021

Mitochondria and apoptosis

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7 January 2021

The modular nature of apoptotic signaling proteins

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7 January 2021

The TNF and TNF receptor superfamilies: integrating mammalian biology

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7 January 2021

Life-or-death decisions by the Bcl-2 protein family.

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7 January 2021

IAP family proteins--suppressors of apoptosis

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7 January 2021

A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis

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7 January 2021

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

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7 January 2021

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

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7 January 2021

Sequence and genomic analysis of a Rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.

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7 January 2021

Inhibition of death receptor signals by cellular FLIP

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7 January 2021

Casper is a FADD- and caspase-related inducer of apoptosis

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7 January 2021

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis

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7 January 2021

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

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7 January 2021

CASH, a novel caspase homologue with death effector domains

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7 January 2021

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death

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7 January 2021

I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis

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7 January 2021

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.

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7 January 2021

Caspases: the executioners of apoptosis

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7 January 2021

The role of c-FLIP in modulation of CD95-induced apoptosis

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7 January 2021

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

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7 January 2021

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

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7 January 2021

CD95's deadly mission in the immune system

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7 January 2021

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

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7 January 2021

TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB

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7 January 2021

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

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7 January 2021

Activation of NF-kappaB by FADD, Casper, and caspase-8.

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7 January 2021

Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins

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7 January 2021

Activation of the NF-kappaB pathway by caspase 8 and its homologs

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7 January 2021

RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis

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7 January 2021

Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice.

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7 January 2021

Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

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7 January 2021

Induction of apoptosis in mature T cells by tumour necrosis factor

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7 January 2021

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

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7 January 2021

Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.

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7 January 2021

Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes

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7 January 2021

Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression

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7 January 2021

TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity

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7 January 2021

Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis.

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7 January 2021

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

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7 January 2021

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

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7 January 2021

A role for FADD in T cell activation and development

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7 January 2021

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

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7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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7 January 2021

NF-kappaB signals induce the expression of c-FLIP.

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7 January 2021

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

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7 January 2021

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

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7 January 2021

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

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7 January 2021

Reduction of thymocyte numbers in transgenic mice expressing viral FLICE-inhibitory protein in a Fas-independent manner.

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7 January 2021

Fas transduces activation signals in normal human T lymphocytes

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7 January 2021

Regulation of apoptosis and T cell activation by Fas-specific mAb.

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7 January 2021

Caspase activation is required for T cell proliferation

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7 January 2021

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

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7 January 2021

p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice

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7 January 2021

Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.

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7 January 2021

Regulation of the Fas death pathway by FLICE-inhibitory protein in primary human B cells

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7 January 2021

Apoptosis by death factor

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7 January 2021

Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages

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7 January 2021

FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis

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7 January 2021

Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory res

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7 January 2021

The immunobiology of multiple sclerosis: an autoimmune disease of the central nervous system

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7 January 2021

Increased cellular expression of the caspase inhibitor FLIP in intrathecal lymphocytes from patients with multiple sclerosis

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7 January 2021

Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins

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7 January 2021

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

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7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

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7 January 2021

Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling

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7 January 2021

Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues

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7 January 2021

Expression of cellular FLICE-inhibitory protein in human coronary arteries and in a rat vascular injury model

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7 January 2021

Endothelial cell apoptosis induced by oxidized LDL is associated with the down-regulation of the cellular caspase inhibitor FLIP.

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7 January 2021

Distinct molecular mechanisms of Fas resistance in murine B lymphoma cells.

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7 January 2021

Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin's lymphoma B cell line.

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7 January 2021

Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors

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7 January 2021

The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors

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7 January 2021

Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein

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7 January 2021

Heterogenous susceptibility to CD95-induced apoptosis in melanoma cells correlates with bcl-2 and bcl-x expression and is sensitive to modulation by interferon-gamma.

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7 January 2021

Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release

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7 January 2021

The Bcl-2 protein family: arbiters of cell survival

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7 January 2021

Identifiers

DOI

10.1038/35095508

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3 August 2017

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PubMed ID

11905814