Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast (Q34573229)

3 August 2017

title

Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast (English)

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3 August 2017

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Cheryl Dixon

1

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3 August 2017

Neal Mathias

2

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3 August 2017

Richard M Zweig

3

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3 August 2017

Donnie A Davis

4

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3 August 2017

David S Gross

5

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3 August 2017

language of work or name

English

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publication date

2 March 2005

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3 August 2017

number of pages

13

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based on heuristic

inferred from page(s)

published in

Genetics

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3 August 2017

volume

170

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3 August 2017

issue

1

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3 August 2017

page(s)

47-59

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Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

3 August 2017

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Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

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7 July 2018

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7 July 2018

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Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations

7 July 2018

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7 July 2018

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7 July 2018

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Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9

7 July 2018

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A di-acidic (DXE) code directs concentration of cargo during export from the endoplasmic reticulum

7 July 2018

1 reference

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

7 July 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

7 July 2018

1 reference

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Alpha-synuclein in Lewy bodies

7 July 2018

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Protein folding. The difference with prokaryotes.

7 July 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

7 July 2018

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

7 July 2018

1 reference

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Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system.

7 July 2018

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Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeast

7 July 2018

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Vesicle fusion from yeast to man

7 July 2018

1 reference

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COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum

7 July 2018

1 reference

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Mechanisms of intracellular protein transport

7 July 2018

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Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis

7 July 2018

1 reference

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

7 July 2018

1 reference

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Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

7 July 2018

1 reference

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Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Basal-level expression of the yeast HSP82 gene requires a heat shock regulatory element

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival

7 July 2018

1 reference

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A simple and efficient procedure for transformation of yeasts

7 July 2018

1 reference

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Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

7 July 2018

1 reference

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Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein

27 October 2018

1 reference

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Proteasomal inhibition by alpha-synuclein filaments and oligomers.

27 October 2018

1 reference

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Yeast cells provide insight into alpha-synuclein biology and pathobiology

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway function

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

27 October 2018

1 reference

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Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

27 October 2018

1 reference

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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

27 October 2018

1 reference

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

27 October 2018

1 reference

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Autosomal dominant Parkinson's disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Understanding cell death in Parkinson's disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Mad cows meet psi-chotic yeast: the expansion of the prion hypothesis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449710

Neuropathology in mice expressing human alpha-synuclein

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15744056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A Raman optical activity study of rheomorphism in caseins, synucleins and tau. New insight into the structure and behaviour of natively unfolded proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15744056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1534/GENETICS.104.035493

1 reference

3 August 2017

1 reference

3 August 2017

1 reference