Trafficking and signaling by fatty-acylated and prenylated proteins (Q34575170)

3 August 2017

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title

Trafficking and signaling by fatty-acylated and prenylated proteins (English)

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3 August 2017

Marilyn D Resh

1

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3 August 2017

publication date

1 November 2006

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3 August 2017

published in

Nature Chemical Biology

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3 August 2017

volume

2

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3 August 2017

issue

11

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3 August 2017

page(s)

584-590

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Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

3 August 2017

cites work

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Fatty acylation and prenylation of proteins: what's hot in fat.

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N-myristoyltransferase 1 is essential in early mouse development

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Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis

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7 January 2021

Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species

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7 January 2021

The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading

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CSS-Palm: palmitoylation site prediction with a clustering and scoring strategy (CSS).

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Protein palmitoylation by a family of DHHC protein S-acyltransferases

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Global analysis of protein palmitoylation in yeast

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Galpha(s) is palmitoylated at the N-terminal glycine

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7 January 2021

Identification of a palmitic acid-modified form of human Sonic hedgehog

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Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion

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Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy

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Binding of acylated peptides and fatty acids to phospholipid vesicles: pertinence to myristoylated proteins

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7 January 2021

Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers.

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7 January 2021

Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids

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7 January 2021

Membrane binding of myristylated peptides corresponding to the NH2 terminus of Src.

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7 January 2021

Myristylation and palmitylation of Src family members: the fats of the matter

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7 January 2021

Electrostatics and the membrane association of Src: theory and experiment

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Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology

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7 January 2021

Retroviral matrix domains share electrostatic homology: models for membrane binding function throughout the viral life cycle

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7 January 2021

Plasma membrane phosphoinositide organization by protein electrostatics

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All ras proteins are polyisoprenylated but only some are palmitoylated

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7 January 2021

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

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7 January 2021

Association of prenylated proteins with the plasma membrane and the inner nuclear membrane is mediated by the same membrane-targeting motifs

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7 January 2021

S-Acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-ras in mammalian fibroblasts

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7 January 2021

Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy

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7 January 2021

K-ras4B and prenylated proteins lacking "second signals" associate dynamically with cellular membranes

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7 January 2021

Portrait of a myristoyl switch protein

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7 January 2021

Structural Basis for Activation of ARF GTPase

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7 January 2021

A myristoyl/phosphotyrosine switch regulates c-Abl

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7 January 2021

Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca2+/calmodulin

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7 January 2021

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

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7 January 2021

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI

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https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Geranylgeranyl switching regulates GDI-Rab GTPase recycling

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https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

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7 January 2021

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway

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https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

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7 January 2021

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

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7 January 2021

Ras signalling on the endoplasmic reticulum and the Golgi

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7 January 2021

Synaptic strength regulated by palmitate cycling on PSD-95.

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7 January 2021

Protein palmitoylation: a regulator of neuronal development and function

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7 January 2021

Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function

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7 January 2021

Regulation of G proteins by covalent modification

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7 January 2021

The stoichiometry of G alpha(s) palmitoylation in its basal and activated states

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7 January 2021

Activation-induced subcellular redistribution of Gs alpha

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7 January 2021

Persistent membrane association of activated and depalmitoylated G protein alpha subunits

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7 January 2021

Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family

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7 January 2021

Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cells

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7 January 2021

Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae

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7 January 2021

Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Lipid rafts and signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

N-myristoylation determines dual targeting of mammalian NADH-cytochrome b5 reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Trafficking of an acylated cytosolic protein: newly synthesized p56(lck) travels to the plasma membrane via the exocytic pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

N-terminal palmitoylation within the appropriate amino acid environment conveys on NOS2 the ability to progress along the intracellular sorting pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Membrane targeting of Rab GTPases is influenced by the prenylation motif

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human delta opioid receptor

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Palmitoylation-dependent control of degradation, life span, and membrane expression of the CCR5 receptor.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Recycling of MUC1 is dependent on its palmitoylation.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Morbid myristoylation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

C-terminal 15 kDa fragment of cytoskeletal actin is posttranslationally N-myristoylated upon caspase-mediated cleavage and targeted to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Posttranslational N-myristoylation is required for the anti-apoptotic activity of human tGelsolin, the C-terminal caspase cleavage product of human gelsolin.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Lipid modification of secreted signaling proteins.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Wnt proteins are lipid-modified and can act as stem cell growth factors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Novel lipid modifications of secreted protein signals

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Lipoprotein particles are required for Hedgehog and Wingless signalling

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

A palmitoylation switch mechanism in the regulation of the visual cycle

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Palmitoylation determines the function of Vac8 at the yeast vacuole

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO834

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO834

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3 August 2017

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