TGF-beta signaling is required for the function of insulin-reactive T regulatory cells (Q34576601)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16670772%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

TGF-beta signaling is required for the function of insulin-reactive T regulatory cells (English)

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20 January 2020

1 reference

2

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20 January 2020

6

Richard A Flavell

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20 January 2020

author name string

Wei Du

1

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20 January 2020

Ming O Li

3

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20 January 2020

Jian Peng

4

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20 January 2020

Hao Qi

5

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20 January 2020

Robert Sherwin

7

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20 January 2020

Li Wen

8

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20 January 2020

language of work or name

English

0 references

publication date

1 May 2006

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Journal of Clinical Investigation

20 January 2020

published in

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20 January 2020

volume

116

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20 January 2020

issue

5

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20 January 2020

page(s)

1360-1370

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

20 January 2020

cites work

1 reference

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7 July 2018

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Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

7 July 2018

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T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

7 July 2018

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Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase

7 July 2018

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

7 July 2018

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Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

7 July 2018

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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

7 July 2018

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Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes

7 July 2018

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Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters

7 July 2018

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Human CD(4+)CD(25+) regulatory T cells and infectious tolerance

7 July 2018

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Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

7 July 2018

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

7 July 2018

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CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer

7 July 2018

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Type 1 T regulatory cells.

7 July 2018

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A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

7 July 2018

1 reference

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Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice

7 July 2018

1 reference

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Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor

7 July 2018

1 reference

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A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue

7 July 2018

1 reference

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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

7 July 2018

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Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes

7 July 2018

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Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells

7 July 2018

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Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1

7 July 2018

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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

7 July 2018

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A mechanism for the major histocompatibility complex-linked resistance to autoimmunity

7 July 2018

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Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice

7 July 2018

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Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse.

7 July 2018

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

7 July 2018

1 reference

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Beta cell apoptosis in T cell-mediated autoimmune diabetes

7 July 2018

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Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)

7 July 2018

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Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice

7 July 2018

1 reference

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Analysis of the spontaneous T cell response to insulin in NOD mice

7 July 2018

1 reference

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Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

7 July 2018

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T-lymphocyte clone specific for pancreatic islet antigen

7 July 2018

1 reference

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

7 July 2018

1 reference

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Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial

7 July 2018

1 reference

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Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

27 October 2018

1 reference

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Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview

27 October 2018

1 reference

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Immune regulation by self-reactive T cells is antigen specific.

27 October 2018

1 reference

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TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice

27 October 2018

1 reference

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Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

27 October 2018

1 reference

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Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy

27 October 2018

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12 December 2020

Following a diabetogenic T cell from genesis through pathogenesis

1 reference

12 December 2020

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1 reference

12 December 2020

Cassette vectors directing expression of T cell receptor genes in transgenic mice

1 reference

12 December 2020

Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice

1 reference

12 December 2020

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

1 reference

12 December 2020

Role of TGFbeta in development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice

1 reference

12 December 2020

Oral tolerance, systemic immunoregulation, and autoimmunity

1 reference

12 December 2020

Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines

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12 December 2020

Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10

1 reference

12 December 2020

Insulin autoantibodies: more specific than proinsulin autoantibodies for prediction of type 1 diabetes

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12 December 2020

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

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12 December 2020

Identifiers

DOI

10.1172/JCI27030

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16670772%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16670772%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference