Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2. (Q34579312)

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English	Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2.	scientific article

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scholarly article

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Europe PubMed Central

3 August 2017

Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2. (English)

1 reference

Europe PubMed Central

3 August 2017

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Yusuf A. Hannun

3

object named as

Yusuf A Hannun

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Europe PubMed Central

3 August 2017

author name string

Christopher J Clarke

1

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Europe PubMed Central

3 August 2017

Thach-Giao Truong

2

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Europe PubMed Central

3 August 2017

language of work or name

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publication date

3 November 2006

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Europe PubMed Central

3 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

3 August 2017

282

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3 August 2017

2

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Europe PubMed Central

3 August 2017

1384-1396

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Europe PubMed Central

3 August 2017

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

1 reference

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Acid and neutral sphingomyelinases: roles and mechanisms of regulation

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Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase

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Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells

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nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis

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Signal transduction by tumor necrosis factor and its relatives

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Involvement of sphingomyelinases in TNF signaling pathways

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Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells

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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism

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Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium

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Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation

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Role of ICAM1 in invasion of human breast cancer cells

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Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators

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Tumor necrosis factor alpha-induced activation of downstream NF-kappaB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion. Involvement of PKCalpha, tyrosine kinase, and IKK2, but not MAPKs, pathway.

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Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, an

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Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis

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Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation

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Tumor necrosis factor-alpha mediated activation of signal transduction cascades and transcription factors in 3T3-L1 adipocytes

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Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation

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p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L).

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TNF-receptor I defective in internalization allows for cell death through activation of neutral sphingomyelinase

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Identifiers

10.1074/JBC.M609216200

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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