The iron metabolism of neoplastic cells: alterations that facilitate proliferation? (Q34581732)

3 August 2017

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title

The iron metabolism of neoplastic cells: alterations that facilitate proliferation? (English)

1 reference

3 August 2017

Juliana C Kwok

1

1 reference

PubMed ID

11923069

3 August 2017

Des R Richardson

series ordinal

2

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3 August 2017

1 April 2002

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Critical Reviews in Oncology Hematology

3 August 2017

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3 August 2017

42

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3 August 2017

1

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3 August 2017

65-78

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Effect of iron chelators with potent anti-proliferative activity on the expression of molecules involved in cell cycle progression and growth

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Modulation of cell surface iron transferrin receptors by cellular density and state of activation

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Regulation of transferrin receptor expression on human leukemic cells during proliferation and induction of differentiation. Effects of gallium and dimethylsulfoxide

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The uptake of iron and transferrin by the human malignant melanoma cell

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Iron withholding: a defense against infection and neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Inactivation of ribonucleotide reductase by nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Iron depletion: possible cause of tumor cell cytotoxicity induced by activated macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Nitric oxide: a cytotoxic activated macrophage effector molecule

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Nitrogen monoxide activates iron regulatory protein 1 RNA-binding activity by two possible mechanisms: effect on the [4Fe-4S] cluster and iron mobilization from cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Nitrogen monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Examination of the mechanism of action of nitrogen monoxide on iron uptake from transferrin

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Transferrin receptors and iron uptake during erythroid cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The mechanisms of iron uptake by fetal rat hepatocytes in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Two saturable mechanisms of iron uptake from transferrin in human melanoma cells: the effect of transferrin concentration, chelators, and metabolic probes on transferrin and iron uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Membrane transport of non-transferrin-bound iron by reticulocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

1 reference

7 January 2021

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The role of ceruloplasmin in iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Ceruloplasmin, transferrin and apotransferrin facilitate iron release from human liver cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Role of ceruloplasmin and ascorbate in cellular iron release

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The release of iron and transferrin from the human melanoma cell

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Aceruloplasminemia: molecular characterization of this disorder of iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Another jigsaw piece towards solving the iron metabolism puzzle: the cloning of the iron exporter, ferroportin1.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Transferrin and iron distribution in subcellular fractions of K562 cells in the early stages of transferrin endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Copper chaperones: function, structure and copper-binding properties.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Ferritin: structure, biosynthesis, and role in iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The ferritins: molecular properties, iron storage function and cellular regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Ferritin in serum. Clinical and biochemical implications

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Serum ferritin: does it differ from tissue ferritin?

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Interferon-gamma and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Iron transport and storage proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Methods for growth of cultured cells in serum-free medium

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Transferrin synthesis by inducer T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Secretion of transferrin by human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Transferrin synthesis by small cell lung cancer cells acts as an autocrine regulator of cellular proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The chicken oviduct and embryonic red blood cell transferrin receptors are distinct molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

An estrogen inducible 104 kDa chaperone glycoprotein binds ferric iron containing proteins: a possible role in intracellular iron trafficking

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Body iron stores and the risk of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Serum transferrin receptor level is not altered in invasive adenocarcinoma of the breast

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Non-transferrin donors of iron for heme synthesis in immature erythroid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The uptake of inorganic iron complexes by human melanoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Identification of a mechanism of iron uptake by cells which is stimulated by hydroxyl radicals generated via the iron-catalysed Haber-Weiss reaction

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Despite structural similarities between gp91phox and FRE1, flavocytochrome b558 does not mediate iron uptake by myeloid cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Functional expression cloning and characterization of SFT, a stimulator of Fe transport

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Structural and functional analysis of SFT, a stimulator of Fe Transport

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Expression of SFT (stimulator of Fe transport) is enhanced by iron chelation in HeLa cells and by hemochromatosis in liver

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Identification of a cell surface protein, p97, in human melanomas and certain other neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Quantitative analysis of melanoma-associated antigen p97 in normal and neoplastic tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Human melanoma-associated antigen p97 is structurally and functionally related to transferrin

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Immunohistochemical detection of antigen in human primary and metastatic melanomas by the monoclonal antibody 140.240 and its possible prognostic significance

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

A transferrin-like GPI-linked iron-binding protein in detergent-insoluble noncaveolar microdomains at the apical surface of fetal intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Expression of membrane-bound transferrin-like protein p97 on the cell surface of chondrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Transferrins: insights into structure and function from studies on lactoferrin

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Human melanotransferrin (p97) has only one functional iron-binding site

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

A novel iron uptake mechanism mediated by GPI-anchored human p97

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The effect of desferrioxamine and ferric ammonium citrate on the uptake of iron by the membrane iron-binding component of human melanoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Reduction of Ribonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: Possible regulation mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

HLA-DR and melanoma-associated antigen (p97) expression during the cell cycle in human melanoma cell lines, and the effects of recombinant gamma-interferon: two-color flow cytometric analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The membrane-bound transferrin homologue melanotransferrin: roles other than iron transport?

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Iron metabolism in eukaryotes: Mars and Venus at it again

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Effect of ceruloplasmin on plasma iron in copper-deficient swine

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Role of ceruloplasmin in cellular iron uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Measurement of Serum Ferritin by Radioimmunoassay: Results in Normal Individuals and Patients With Breast Cancer 2

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Serum and tumour ferritins in primary liver cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Neuroblastomas contain iron-rich ferritin

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Iron and neoplasia: ferritin and hemosiderin in tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Biologic differences between neuroblastoma stages IV-S and IV. Measurement of serum ferritin and E-rosette inhibition in 30 children

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Mutated recombinant human heavy-chain ferritins and myelosuppression in vitro and in vivo: a link between ferritin ferroxidase activity and biological function

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Identification of leukemia-associated inhibitory activity as acidic isoferritins. A regulatory role for acidic isoferritins in the production of granulocytes and macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Basic and acidic isoferritins in the sera of patients with neuroblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Purification of a cell growth factor from a human lung cancer cell line: its relationship with ferritin

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Interaction of acidic isoferritins with human promyelocytic HL60 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Identification of H- and L-ferritin subunit binding sites on human T and B lymphoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Specific binding of placental acidic isoferritin to cells of the T-cell line HD-MAR.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Distribution of ferritin receptors and coated pits on giant HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Increased expression of cytokeratin and ferritin-H genes in tumorigenic clones of the SW 613-S human colon carcinoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900213-X

7 January 2021

10.1016/S1040-8428(01)00213-X

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11923069