Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo (Q34581860)

3 August 2017

title

Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo (English)

1 reference

3 August 2017

1 reference

1 reference

9

Paul Dent

1 reference

3 August 2017

8

Kenneth P Nephew

1 reference

3 August 2017

Clint Mitchell

1

1 reference

3 August 2017

Adly Yacoub

2

1 reference

3 August 2017

Hamed Hossein

3

1 reference

3 August 2017

Aditi Pandya Martin

4

1 reference

3 August 2017

Patrick Eulitt

6

1 reference

3 August 2017

Chen Yang

7

1 reference

3 August 2017

M. Danielle Bareford

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855960

17 July 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20855960

17 July 2024

publication date

1 November 2010

1 reference

full work available at URL

3 August 2017

https://www.tandfonline.com/doi/pdf/10.4161/cbt.10.9.13273?needAccess=true

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855960

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20855960/pdf/?tool=EBI

17 July 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855960

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20855960/?tool=EBI

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855960

https://europepmc.org/articles/PMC3040858

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855960

https://europepmc.org/articles/PMC3040858?pdf=render

17 July 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855960

https://doi.org/10.4161/cbt.10.9.13273

17 July 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855960

http://www.tandfonline.com/doi/pdf/10.4161/cbt.10.9.13273

17 July 2024

1 reference

DOI

10.4161/CBT.10.9.13273

https://api.crossref.org/works/10.4161/CBT.10.9.13273

Cancer Biology and Therapy

17 July 2024

published in

1 reference

3 August 2017

volume

10

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3 August 2017

issue

9

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3 August 2017

page(s)

903-917

1 reference

Survival benefits from lapatinib therapy in women with HER2-overexpressing breast cancer: a systematic review.

3 August 2017

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7 July 2018

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Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status

7 July 2018

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7 July 2018

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Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

7 July 2018

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7 July 2018

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Clinical activities of the epidermal growth factor receptor family inhibitors in breast cancer

7 July 2018

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect

7 July 2018

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Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

7 July 2018

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ABT-737 synergizes with chemotherapy to kill head and neck squamous cell carcinoma cells via a Noxa-mediated pathway

7 July 2018

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7 July 2018

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Establishment and characterization of a model of acquired resistance to epidermal growth factor receptor targeting agents in human cancer cells.

7 July 2018

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Tyrosine kinase blockers: new hope for successful cancer therapy.

7 July 2018

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Gefitinib for the treatment of non-small-cell lung cancer

7 July 2018

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Is the focus moving toward a combination of targeted drugs?

7 July 2018

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Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer

7 July 2018

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Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.

7 July 2018

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Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

7 July 2018

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Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

7 July 2018

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Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling

7 July 2018

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Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation

7 July 2018

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Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.

7 July 2018

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Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells

7 July 2018

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OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells

7 July 2018

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MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

7 July 2018

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Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

7 July 2018

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Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

7 July 2018

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7 July 2018

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7 July 2018

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Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

7 July 2018

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Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

7 July 2018

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Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol

7 July 2018

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Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).

21 January 2018

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Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol

21 January 2018

1 reference

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PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells

21 January 2018

1 reference

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The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1.

21 January 2018

1 reference

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Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol

27 October 2018

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27 October 2018

Identifiers

DOI

10.4161/CBT.10.9.13273

1 reference

3 August 2017

1 reference

3 August 2017

1 reference