Orlistat-associated adverse effects and drug interactions: a critical review (Q34586250)

3 August 2017

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title

Orlistat-associated adverse effects and drug interactions: a critical review (English)

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3 August 2017

Dimitri P Mikhailidis

5

object named as

Dimitri P Mikhailidis

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3 August 2017

Theodosios D Filippatos

1

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3 August 2017

Christos S Derdemezis

2

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3 August 2017

Irene F Gazi

3

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3 August 2017

Eleni S Nakou

4

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3 August 2017

Moses S Elisaf

6

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3 August 2017

1 January 2008

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3 August 2017

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3 August 2017

31

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3 August 2017

53-65

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3 August 2017

1

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https://scigraph.springernature.com/pub.10.2165/00002018-200831010-00005

3 August 2017

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cites work

Orlistat augments postprandial increases in glucagon-like peptide 1 in obese type 2 diabetic patients

1 reference

12 December 2020

Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial

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12 December 2020

Orlistat associated with hypertension. Roche concludes that there is not evidence of a casual association

1 reference

12 December 2020

Orlistat in the treatment of clozapine-induced hyperglycemia and weight gain

1 reference

12 December 2020

A rapid and systematic review of the clinical effectiveness and cost-effectiveness of orlistat in the management of obesity

1 reference

12 December 2020

The influence of orlistat on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers.

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12 December 2020

The effect of orlistat on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers

1 reference

12 December 2020

The effect of orlistat, an inhibitor of dietary fat absorption, on the absorption of vitamins A and E in healthy volunteers

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12 December 2020

Effects of a high-fat diet on azoxymethane-induced aberrant crypt foci and fecal biochemistry and microbial activity in rats

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12 December 2020

Treatment with orlistat reduces cardiovascular risk in obese patients

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12 December 2020

Rapidly progressive renal failure associated with successful pharmacotherapy for obesity

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12 December 2020

Effect of orlistat on blood cyclosporin concentration in an obese heart transplant patient

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12 December 2020

Orlistat decreases the plasma level of cyclosporine and may be responsible for the development of acute rejection episodes

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12 December 2020

Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials

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12 December 2020

Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metformin

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12 December 2020

Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?

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12 December 2020

Reduction in blood cyclosporine concentrations by orlistat

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12 December 2020

Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial

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12 December 2020

Interactions between cyclosporin and lipid-lowering drugs: implications for organ transplant recipients

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12 December 2020

The effect of orlistat on the pharmacokinetics of phenytoin in healthy volunteers

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12 December 2020

Reduced absorption of lipophilic anti-epileptic medications when used concomitantly with the anti-obesity drug orlistat

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12 December 2020

Effects of a lipase inhibitor (Orlistat) on cholecystokinin and appetite in response to a high-fat meal

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12 December 2020

Randomized, double-blind, placebo-controlled comparison of the action of orlistat, fluvastatin, or both an anthropometric measurements, blood pressure, and lipid profile in obese patients with hypercholesterolemia prescribed a standardized diet

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12 December 2020

Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement

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12 December 2020

Effects of sibutramine and orlistat on mood in obese and overweight subjects: a randomised study.

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12 December 2020

Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers

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12 December 2020

Orlistat is as beneficial as metformin in the treatment of polycystic ovarian syndrome.

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12 December 2020

Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial

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12 December 2020

Effect of weight loss on blood pressure, arterial compliance, and insulin resistance in normotensive obese subjects

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12 December 2020

Long-term systemic exposure of orlistat, a lipase inhibitor, and its metabolites in obese patients

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12 December 2020

Excessive weight gain after remission of depression in a schizophrenic patient treated with risperidone: case report

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12 December 2020

A pilot study of orlistat treatment in obese, non-alcoholic steatohepatitis patients

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12 December 2020

The effect of orlistat on plasma levels of psychotropic drugs in patients with long-term psychopharmacotherapy

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12 December 2020

Orlistat-induced cutaneous leukocytoclastic vasculitis

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12 December 2020

Role of orlistat in the treatment of obese patients with type 2 diabetes. A 1-year randomized double-blind study.

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12 December 2020

A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice

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12 December 2020

Short-term orlistat treatment does not affect mineral balance and bone turnover in obese men.

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12 December 2020

The influence of a 3-month weight reduction therapy with Orlistat on serum vitamin B12 and folic acid concentration in obese women.

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12 December 2020

Orlistat in hypertensive overweight/obese patients: results of a randomized clinical trial

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12 December 2020

Orlistat enhances warfarin effect

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12 December 2020

Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers

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12 December 2020

Effect of orlistat, micronised fenofibrate and their combination on metabolic parameters in overweight and obese patients with the metabolic syndrome: the FenOrli study

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12 December 2020

Latin-American trial of orlistat for weight loss and improvement in glycaemic profile in obese diabetic patients

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12 December 2020

A randomized study of orlistat in combination with a weight management programme in obese patients with Type 2 diabetes treated with metformin

1 reference

12 December 2020

Orlistat as an adjunct therapy in type 2 obese diabetic patients treated with sulphonylurea: a Bangladesh experience

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12 December 2020

Preventing type 2 diabetes in high risk patients: an overview of lifestyle and pharmacological measures.

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12 December 2020

Orlistat: from antiobesity drug to anticancer agent in Her-2/neu (erbB-2)-overexpressing gastrointestinal tumors?

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12 December 2020

Effect of long-term orlistat treatment on serum levels of advanced glycation end-products in women with polycystic ovary syndrome.

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12 December 2020

Effect of orlistat on weight regain and cardiovascular risk factors following a very-low-energy diet in abdominally obese patients: a 3-year randomized, placebo-controlled study.

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12 December 2020

The ORLIstat and CArdiovascular risk profile in patients with metabolic syndrome and type 2 DIAbetes (ORLICARDIA) Study

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12 December 2020

The anti-obesity agent Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen

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12 December 2020

Lowering of LDL cholesterol rather than moderate weight loss improves endothelium-dependent vasodilatation in obese women with previous gestational diabetes

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12 December 2020

Mode of action of orlistat

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12 December 2020

Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene

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12 December 2020

XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients

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12 December 2020

Effect of orlistat-induced weight loss on blood pressure and heart rate in obese patients with hypertension

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12 December 2020

Pharmacokinetic evaluation of the possible interaction between selected concomitant medications and orlistat at steady state in healthy subjects

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12 December 2020

The antiobesity drug Orlistat induces cytotoxic effects, suppresses Her-2/neu (erbB-2) oncogene overexpression, and synergistically interacts with trastuzumab (Herceptin) in chemoresistant ovarian cancer cells.

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12 December 2020

[Effect of orlistat therapy on carbohydrate, lipid, vitamin and hormone plasma levels in obese subjects]

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12 December 2020

Major depressive episodes and diet pills

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12 December 2020

Influence of orlistat on the regulation of gallbladder contraction in man: a randomized double-blind placebo-controlled crossover study.

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12 December 2020

Fat malabsorption induced by gastrointestinal lipase inhibitor leads to an increase in urinary oxalate excretion

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12 December 2020

A review of the metabolic effects of sibutramine.

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12 December 2020

X-PERT: weight reduction with orlistat in obese subjects receiving a mildly or moderately reduced-energy diet: early response to treatment predicts weight maintenance.

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12 December 2020

The interaction of the lipase inhibitor orlistat with ethanol in healthy volunteers

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12 December 2020

Effect of the lipase inhibitor orlistat on the pharmacokinetics of four different antihypertensive drugs in healthy volunteers

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12 December 2020

36 year old man presenting with pancreatitis and a history of recent commencement of Orlistat case report

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12 December 2020

Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers

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12 December 2020

Randomised trial of the effect of orlistat on body weight and cardiovascular disease risk profile in obese patients: UK Multimorbidity Study.

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12 December 2020

Reduction in blood cyclosporine concentration by orlistat in two renal transplant patients

1 reference

12 December 2020

Orlistat (Xenical)-induced subacute liver failure

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12 December 2020

Effect of orlistat in overweight poorly controlled Chinese female type 2 diabetic patients: a randomised, double-blind, placebo-controlled study.

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12 December 2020

Bulimia nervosa and misuse of orlistat: two case reports

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12 December 2020

The effect of orlistat, an inhibitor of dietary fat absorption, on the pharmacokinetics of beta-carotene in healthy volunteers

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12 December 2020

Effect of orlistat in obese patients with binge eating disorder

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12 December 2020

Leptin: a promising therapeutic target with pleiotropic action besides body weight regulation

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12 December 2020

Depression induced by orlistat (Xenical)

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12 December 2020

The effects of orlistat in patients with diabetes: improvement in glycaemic control and weight loss

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12 December 2020

Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor

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12 December 2020

Acute oxalate nephropathy associated with orlistat, a gastrointestinal lipase inhibitor

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12 December 2020

Effects of orlistat on fat-soluble vitamins in obese adolescents

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12 December 2020

Constipation, polyuria, polydipsia, and edema associated with orlistat

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12 December 2020

Efficacy and safety comparative evaluation of orlistat and sibutramine treatment in hypertensive obese patients

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12 December 2020

Lack of effect of orlistat on the bioavailability of a single dose of nifedipine extended-release tablets (Procardia XL) in healthy volunteers

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12 December 2020

Drug treatments for obesity: orlistat, sibutramine, and rimonabant.

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12 December 2020

The effect of orlistat-induced weight loss, without concomitant hypocaloric diet, on cardiovascular risk factors and insulin sensitivity in young obese Chinese subjects with or without type 2 diabetes

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12 December 2020

Safety profile of orlistat: results of a prescription-event monitoring study

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12 December 2020

Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group.

1 reference

12 December 2020

Comparison of metabolic effects of orlistat and sibutramine treatment in Type 2 diabetic obese patients.

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12 December 2020

Dietary fat quantity and composition induce changes in proliferation and membrane lipids in rat colon cells

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12 December 2020

Diabetic ketoacidosis associated with orlistat treatment

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12 December 2020

Massive hepatocellular [correction of hepatocullular] necrosis: was it caused by Orlistat?

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12 December 2020

Bone loss accompanying diet-induced or exercise-induced weight loss: a randomised controlled study

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12 December 2020

Incorrect use of orlistat and sibutramine in clinical practice

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12 December 2020

The Effect of Short-Term (21-Day) Orlistat Treatment on the Physiologic Balance of Six Selected Macrominerals and Microminerals in Obese Adolescents

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12 December 2020

Effects of lipase inhibition on gastric emptying and alcohol absorption in healthy subjects

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12 December 2020

Lack of interaction between orlistat and oral contraceptives

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12 December 2020

A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease

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12 December 2020

Caution when using oral contraceptive pills with Orlistat

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12 December 2020

Obesity in transplant patients: case report showing interference of orlistat with absorption of cyclosporine and review of literature

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12 December 2020

Orlistat associated with hypertension

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12 December 2020

Lichenoid eruption associated with orlistat

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12 December 2020

Efficacy and tolerability of orlistat in the treatment of obesity: a 6-month dose-ranging study. Orlistat Dose-Ranging Study Group

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12 December 2020

Effects of lipase inhibition on gastric emptying of, and on the glycaemic, insulin and cardiovascular responses to, a high-fat/carbohydrate meal in type 2 diabetes

1 reference

12 December 2020

The effect of orlistat and fenofibrate, alone or in combination, on small dense LDL and lipoprotein-associated phospholipase A2 in obese patients with metabolic syndrome

1 reference

12 December 2020

Effects of Orlistat, a Lipase Inhibitor, on the Pharmacokinetics of Three Highly Lipophilic Drugs (Amiodarone, Fluoxetine, and Simvastatin) in Healthy Volunteers

1 reference

12 December 2020

The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo-controlled trial

1 reference

12 December 2020

A systematic review of the clinical effectiveness of orlistat used for the management of obesity.

1 reference

12 December 2020

Short-term effect of orlistat on dietary glycotoxins in healthy women and women with polycystic ovary syndrome

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12 December 2020

The effects of orlistat on metabolic parameters and other cardiovascular risk factors.

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12 December 2020

Gastrointestinal side effects of orlistat may be prevented by concomitant prescription of natural fibers (psyllium mucilloid)

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12 December 2020

Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomised study.

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12 December 2020

Orlistat improves blood pressure control in obese subjects with treated but inadequately controlled hypertension

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12 December 2020

Severe hepatic injury caused by orlistat

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12 December 2020

Effect of lipase inhibition on gastric emptying of, and the glycemic and incretin responses to, an oil/aqueous drink in type 2 diabetes mellitus

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12 December 2020

The pathophysiology of faecal spotting in obese subjects during treatment with orlistat

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12 December 2020

Efficacy of sibutramine, orlistat and combination therapy on short-term weight management in obese patients

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12 December 2020

Co-administration of orlistat and cyclosporine in a heart transplant recipient

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12 December 2020

Orlistat associated with hypertension. Digit preference lays conclusions about orlistat open to doubt

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12 December 2020

Influence of orlistat on bone turnover and body composition

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12 December 2020

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

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12 December 2020

Effects of orlistat and its relationship with nitric oxide in the small intestinal mucosa

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12 December 2020

Treatment of intractable constipation with orlistat: a report of three cases

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12 December 2020

Drug interaction in a renal transplant patient: cyclosporin-Neoral and orlistat

1 reference

12 December 2020

A case of acute cholestatic hepatitis associated with Orlistat

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12 December 2020

Pharmacological treatment of non-alcoholic steatohepatitis: the current evidence.

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12 December 2020

The effects of loperamide on continence problems and anorectal function in obese subjects taking orlistat

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12 December 2020

Orlistat and cardiovascular risk profile in hypertensive patients with metabolic syndrome: the ARCOS study

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12 December 2020

Hypothyroidism in thyroid carcinoma follow-up: orlistat may inhibit the absorption of thyroxine

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12 December 2020

Metabolic profiles of minimally absorbed orlistat in obese/overweight volunteers

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12 December 2020

Orlistat associated subacute hepatic failure

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12 December 2020

Comparison of the effect of orlistat vs orlistat plus metformin on weight loss and insulin resistance in obese women

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12 December 2020

Effect of orlistat-assisted weight loss in decreasing coronary heart disease risk in patients with syndrome X.

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12 December 2020

Additive gastrointestinal effects with concomitant use of olestra and orlistat

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12 December 2020

10.2165/00002018-200831010-00005

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DOI

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Dimensions Publication ID

3 August 2017

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