Mechanisms linking obesity with cardiovascular disease (Q34590832)

3 August 2017

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title

Mechanisms linking obesity with cardiovascular disease (English)

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3 August 2017

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cardiovascular disease

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Luc F Van Gaal

1

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3 August 2017

Ilse L Mertens

series ordinal

2

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3 August 2017

Christophe E De Block

series ordinal

3

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3 August 2017

language of work or name

English

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publication date

1 December 2006

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3 August 2017

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3 August 2017

444

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3 August 2017

875-880

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3 August 2017

7121

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https://scigraph.springernature.com/pub.10.1038/nature05487

3 August 2017

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cites work

The obesity epidemic, metabolic syndrome and future prevention strategies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Obesity and the risk of heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Adiposity as Compared with Physical Activity in Predicting Mortality among Women

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

A potential decline in life expectancy in the United States in the 21st century

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Ph

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Obesity in Adulthood and Its Consequences for Life Expectancy: A Life-Table Analysis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Fitness and fatness as predictors of mortality from all causes and from cardiovascular disease in men and women in the lipid research clinics study

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

The influence of smoking on soluble adhesion molecules and endothelial cell markers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Association of hypoadiponectinemia with smoking habit in men.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

The metabolic syndrome and adipocytokines

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

The expression and functional role of nicotinic acetylcholine receptors in rat adipocytes

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https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Insulin resistance and cigarette smoking

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Acute effects of cigarette smoke on inflammation and oxidative stress: a review

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Obesity and dyslipidemia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Relationships of abdominal obesity and hyperinsulinemia to angiographically assessed coronary artery disease in men with known mutations in the LDL receptor gene.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Effects of Obesity on Lipid-Lowering, Anti-Inflammatory, and Antiatherosclerotic Benefits of Atorvastatin or Pravastatin in Patients With Coronary Artery Disease (from the REVERSAL Study)

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Clinical relevance of the biochemical, metabolic, and genetic factors that influence low-density lipoprotein heterogeneity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

LDL cholesterol as a strong predictor of coronary heart disease in diabetic individuals with insulin resistance and low LDL: The Strong Heart Study

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Apolipoprotein B-100 kinetics in visceral obesity: associations with plasma apolipoprotein C-III concentration

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

New International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment panel III (NCEP-ATPIII) criteria and the involvement of hemostasis and fibrinolysis in the metabolic syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

The fitness, obesity, and health equation: is physical activity the common denominator?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Obesity as compared with physical activity in predicting risk of coronary heart disease in women

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Body Weight and Mortality among Women

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Physical fitness as a predictor of mortality among healthy, middle-aged Norwegian men

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Insulin Resistance and Atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Is insulin resistance atherogenic? A review of the evidence

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Free fatty acids and atherosclerosis--guilty or innocent?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Ceramides in insulin resistance and lipotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Abdominal adiposity and coronary heart disease in women

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Treatment of obesity: need to focus on high risk abdominally obese patients

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Visceral Fat Is an Independent Predictor of All-cause Mortality in Men*

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

The fatty liver and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Lipotoxic heart disease in obese rats: implications for human obesity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Adiposity of the heart, revisited

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Hemostasis and fibrinolysis in non-diabetic overweight and obese men and women. Is there still a role for leptin?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Association of hypoadiponectinemia with impaired vasoreactivity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

RETRACTED: Visfatin: a protein secreted by visceral fat that mimics the effects of insulin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

The release of the adipocytokine visfatin is regulated by glucose and insulin.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Obesity, haemostasis and the fibrinolytic system

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Stromal cells are the main plasminogen activator inhibitor-1-producing cells in human fat: evidence of differences between visceral and subcutaneous deposits.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

PAI-1 and the metabolic syndrome: links, causes, and consequences

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

The interactions between inflammation and coagulation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Metabolic and inflammation variable clusters and prediction of type 2 diabetes: factor analysis using directly measured insulin sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Inflammation and atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Adipose tissue, inflammation, and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05487

7 January 2021

Identifiers

DOI

10.1038/NATURE05487

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Dimensions Publication ID

3 August 2017

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