Designing substrate specificity by protein engineering of electrostatic interactions (Q34599696)

3 August 2017

Designing substrate specificity by protein engineering of electrostatic interactions (English)

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3 August 2017

Wells JA

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3 August 2017

Powers DB

2

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3 August 2017

Bott RR

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3 August 2017

Graycar TP

4

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3 August 2017

Estell DA

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3 August 2017

language of work or name

English

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publication date

1 March 1987

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Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

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3 August 2017

84

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3 August 2017

5

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3 August 2017

1219-1223

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The mechanism of the reaction of chymotrypsin with p-nitrophenyl acetate

3 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

In VitroDeletional Mutagenesis for Bacterial Production of the 20,000-Dalton Form of Human Pituitary Growth Hormone

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Cloning, sequencing, and secretion of Bacillusamyloliquefacienssubtillisin inBacillus subtilis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Calculations of electrostatic interactions in biological systems and in solutions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

On the size of the active site in proteases. I. Papain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Analysis of the binding of phenylalanine to phenylalanyl-tRNA synthetase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Supercoil sequencing: a fast and simple method for sequencing plasmid DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Engineering an enzyme by site-directed mutagenesis to be resistant to chemical oxidation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

pH-dependent processes in proteins.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Hydrogen bonding and biological specificity analysed by protein engineering

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Electrostatic interactions in membranes and proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Electrostatic effects in proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

Experimental evaluation of the effective dielectric constant of proteins

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=304398

26 October 2018

1 reference

12 December 2020

Electrostatic effects in proteins

1 reference

12 December 2020

Conformational equilibria in -and -chymotrypsin. The energetics and importance of the salt bridge

1 reference

12 December 2020

Redesigning trypsin: alteration of substrate specificity

1 reference

12 December 2020

Subtilisin. Stereochemical mechanism involving transition-state stabilization

1 reference

12 December 2020

Polypeptide halomethyl ketones bind to serine proteases as analogs of the tetrahedral intermediate. X-ray crystallographic comparison of lysine- and phenylalanine-polypeptide chloromethyl ketone-inhibited subtilisin

1 reference

12 December 2020

An x-ray crystallographic study of the binding of peptide chloromethyl ketone inhibitors to subtilisin BPN'

1 reference

12 December 2020

Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation

1 reference

12 December 2020

Directed mutagenesis of dihydrofolate reductase

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.84.5.1219

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3 August 2017

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3 August 2017

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