TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling (Q34603534)

3 August 2017

title

TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling (English)

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3 August 2017

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Yong-Jing Gao

7

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Ru-Rong Ji

object named as

Ru-Rong Ji

6

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author name string

Ying Lu

1

1 reference

3 August 2017

Bao-Chun Jiang

2

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3 August 2017

De-Li Cao

3

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3 August 2017

Zhi-Jun Zhang

4

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3 August 2017

Xin Zhang

5

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3 August 2017

language of work or name

English

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publication date

19 October 2014

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3 August 2017

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3 August 2017

volume

155

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3 August 2017

issue

12

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3 August 2017

page(s)

2618-2629

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Bupleurum polysaccharides attenuates lipopolysaccharide-induced inflammation via modulating Toll-like receptor 4 signaling

3 August 2017

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7 July 2018

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Glia and pain: is chronic pain a gliopathy?

7 July 2018

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TRAF6 and p62 inhibit amyloid β-induced neuronal death through p75 neurotrophin receptor

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Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.

7 July 2018

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Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1

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Chemokines, neuronal-glial interactions, and central processing of neuropathic pain

7 July 2018

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The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition

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JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain

7 July 2018

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Supraspinal glial-neuronal interactions contribute to descending pain facilitation

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7 July 2018

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7 July 2018

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The neuropathic pain triad: neurons, immune cells and glia

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Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway

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The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat

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A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

7 July 2018

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Immune and inflammatory mechanisms in neuropathic pain

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Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

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Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia.

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TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.

7 July 2018

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Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.

7 July 2018

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Lipopolysaccharide signals an endothelial apoptosis pathway through TNF receptor-associated factor 6-mediated activation of c-Jun NH2-terminal kinase

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Distinct molecular mechanism for initiating TRAF6 signalling

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ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.

7 July 2018

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7 July 2018

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7 July 2018

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The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

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TRAF6 is a signal transducer for interleukin-1

7 July 2018

1 reference

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7 July 2018

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An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

7 July 2018

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7 July 2018

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Increased Expression of TNF Receptor-Associated Factor 6 After Rat Traumatic Brain Injury

26 October 2018

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TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.

26 October 2018

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Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.

26 October 2018

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Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model.

26 October 2018

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TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord

26 October 2018

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p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

26 October 2018

1 reference

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Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.

26 October 2018

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Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus

26 October 2018

1 reference

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Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment

26 October 2018

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CD40 ligation stimulates MCP-1 and IL-8 production, TRAF6 recruitment, and MAPK activation in proximal tubule cells

26 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25267210

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intrathecal morphine in mice: a new technique

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25267210

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of complete Freund's adjuvant on immunohistochemical distribution of IL-1beta and IL-1R I in neurons and glia cells of dorsal root ganglion

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25267210

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.PAIN.2014.09.027

1 reference

3 August 2017

1 reference

3 August 2017

1 reference