Classical and novel retinoids: their targets in cancer therapy (Q34605217)

3 August 2017

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title

Classical and novel retinoids: their targets in cancer therapy (English)

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3 August 2017

Fontana JA

1

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PubMed ID

11960323

3 August 2017

Rishi AK

series ordinal

2

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3 August 2017

1 April 2002

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3 August 2017

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3 August 2017

16

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3 August 2017

4

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3 August 2017

463-472

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402414

3 August 2017

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9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

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7 January 2021

Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping

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7 January 2021

The N-terminal portion of domain E of retinoic acid receptors alpha and beta is essential for the recognition of retinoic acid and various analogs

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7 January 2021

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

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7 January 2021

Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism

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7 January 2021

Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment

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7 January 2021

Nuclear receptor that identifies a novel retinoic acid response pathway

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7 January 2021

Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity

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7 January 2021

Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific

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7 January 2021

Antagonism between retinoic acid receptors

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7 January 2021

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

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7 January 2021

Role of CBP/P300 in nuclear receptor signalling

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7 January 2021

6'-substituted naphthalene-2-carboxylic acid analogs, a new class of retinoic acid receptor subtype-specific ligands

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7 January 2021

Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma

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7 January 2021

Retinoids selective for retinoid X receptor response pathways

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7 January 2021

Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity

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7 January 2021

Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids

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7 January 2021

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7 January 2021

All-trans retinoic acid for acute promyelocytic leukemia. Results of the New York Study

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7 January 2021

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

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7 January 2021

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

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7 January 2021

Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).

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7 January 2021

A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage

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7 January 2021

Function of RARalpha during the maturation of neutrophils

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7 January 2021

Transcriptional regulation in acute promyelocytic leukemia.

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7 January 2021

Positive and negative regulation of granulopoiesis by endogenous RARalpha

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7 January 2021

The molecular biology of acute promyelocytic leukemia

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7 January 2021

Transgenic expression of PML/RARalpha impairs myelopoiesis

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7 January 2021

The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1

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7 January 2021

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

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7 January 2021

Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

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7 January 2021

Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.

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7 January 2021

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

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7 January 2021

Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha

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7 January 2021

Pulsed ATRA as single therapy restores long-term remission in PML-RARalpha-positive acute promyelocytic leukemia patients: real time quantification of minimal residual disease. A pilot study.

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7 January 2021

N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma

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7 January 2021

4-Hydroxyphenyl retinamide is a highly selective activator of retinoid receptors

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7 January 2021

Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide

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7 January 2021

Inhibition of cancer cell growth by all-trans retinoic acid and its analog N-(4-hydroxyphenyl) retinamide: a possible mechanism of action via regulation of retinoid receptors expression.

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7 January 2021

Induction of apoptosis by fenretinide (4HPR) in human ovarian carcinoma cells and its association with retinoic acid receptor expression

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7 January 2021

Effector mechanisms of fenretinide-induced apoptosis in neuroblastoma.

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7 January 2021

Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells

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7 January 2021

Role of antioxidants and intracellular free radicals in retinamide-induced cell death.

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7 January 2021

Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells.

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Suppression of cell proliferation and telomerase activity in 4-(hydroxyphenyl)retinamide-treated mammary tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

pRb and Cdk regulation by N-(4-hydroxyphenyl)retinamide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Differential effects of retinoic acid (RA) and N-(4-hydroxyphenyl) retinamide (4-HPR) on cell growth, induction of differentiation, and changes in p34cdc2, Bcl-2, and actin expression in the human promyelocytic HL-60 leukemic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Safety of the synthetic retinoid fenretinide: long-term results from a controlled clinical trial for the prevention of contralateral breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Fenretinide and cancer prevention

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Prevention of local relapses and new localisations of oral leukoplakias with the synthetic retinoid fenretinide (4-HPR). Preliminary results

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Effects of receptor class- and subtype-selective retinoids and an apoptosis-inducing retinoid on the adherent growth of the NIH:OVCAR-3 ovarian cancer cell line in culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Synthetic retinoid CD437 induces S-phase arrest and apoptosis in human prostate cancer cells LNCaP and PC-3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Identification of a unique binding protein specific for a novel retinoid inducing cellular apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Growth-inhibitory effects of the synthetic retinoid CD437 against ovarian carcinoma models in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402414

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402414

1 reference

PubMed ID

11960323

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

11960323