Dysregulation of unfolded protein response partially underlies proapoptotic activity of bortezomib in multiple myeloma cells (Q34606889)

3 August 2017

title

Dysregulation of unfolded protein response partially underlies proapoptotic activity of bortezomib in multiple myeloma cells (English)

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3 August 2017

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Hongjuan Dong

1

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3 August 2017

Liang Chen

2

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3 August 2017

Xiequn Chen

3

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3 August 2017

Hongtao Gu

4

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3 August 2017

Guangxun Gao

5

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3 August 2017

Ying Gao

6

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3 August 2017

Baoxia Dong

7

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3 August 2017

publication date

1 June 2009

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3 August 2017

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3 August 2017

volume

50

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3 August 2017

issue

6

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3 August 2017

page(s)

974-984

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The endoplasmic reticulum is a key component of the plasma cell death pathway

3 August 2017

cites work

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IRE1 signaling affects cell fate during the unfolded protein response

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A trip to the ER: coping with stress

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Progressively impaired proteasomal capacity during terminal plasma cell differentiation

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Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

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Organelle-specific initiation of cell death pathways

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

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Plasma cell differentiation requires the transcription factor XBP-1

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The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

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Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

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Proteasome inhibitor bortezomib for the treatment of multiple myeloma.

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The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

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Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression

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NF-kappa B as a therapeutic target in multiple myeloma

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Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications

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Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.

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Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells

21 January 2018

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Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma

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Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.

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Activation of mitogen-activated protein kinase through alpha5/beta1 integrin is required for cell cycle progression of B progenitor cell line, Reh, on human marrow stromal cells

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Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

21 January 2018

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Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex

21 January 2018

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

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Flavivirus Infection Activates the XBP1 Pathway of the Unfolded Protein Response To Cope with Endoplasmic Reticulum Stress

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Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

21 January 2018

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Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion

21 January 2018

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RNA interference: the new somatic cell genetics?

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

21 January 2018

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Cellular response to endoplasmic reticulum stress: a matter of life or death

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10.1080/10428190902895780

21 January 2018

Identifiers

DOI

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3 August 2017

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