Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination (Q34620251)

3 August 2017

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title

Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination (English)

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growth delay due to insulin-like growth factor type 1 deficiency

3 August 2017

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1 reference

5

William T Cefalu

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3 August 2017

Christy S Carter

1

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3 August 2017

Melinda M Ramsey

2

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3 August 2017

Rhonda L Ingram

3

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3 August 2017

Adrienne B Cashion

4

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3 August 2017

Z Q Wang

6

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3 August 2017

William E Sonntag

7

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3 August 2017

language of work or name

English

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publication date

1 May 2002

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The Journals of Gerontology

3 August 2017

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3 August 2017

57

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3 August 2017

B177-88

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3 August 2017

5

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A C. elegans mutant that lives twice as long as wild type

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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

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Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

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Regulation of longevity and stress resistance by Sch9 in yeast

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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

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Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

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Low body temperature in long-lived Ames dwarf mice at rest and during stress.

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Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters.

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Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice.

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Inhibitory avoidance and appetitive learning in aged normal mice: comparison with transgenic mice having elevated plasma growth hormone levels.

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Kleemeier award lecture: are there genes for aging?

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Prolonged longevity of hypopituitary dwarf mice

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Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.

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The somatomedin hypothesis: 2001.

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Growth hormone induces somatostatin and insulin-like growth factor I gene expression in the cerebral hemispheres of aging rats

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Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: a further potential site of growth hormone regulation of IGF-I action

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A personal history of the origin of the somatomedin hypothesis and recent challenges to its validity

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Impaired growth hormone secretion in the adult population: relation to age and adiposity

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Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory.

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Effects of human growth hormone in men over 60 years old

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Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals

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Effects of long-term, low-dose growth hormone therapy on immune function and life expectancy of mice

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DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE.

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Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

21 January 2018

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Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

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Dwarf mice and the ageing process.

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Inherited Ateliotic Dwarfism in Mice: Characteristics of the mutation, little, on Chromosome 6

21 January 2018

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Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system

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Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice.

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Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice

21 January 2018

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Increased insulin-like growth factor-I (IGF-I) expression during early postnatal development differentially increases neuron number and growth in medullary nuclei of the mouse.

21 January 2018

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Androgens and aging in men.

21 January 2018

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Development of cholinergic neurons in rat brain regions: dose-dependent effects of propylthiouracil-induced hypothyroidism.

21 January 2018

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Effects of thyroid deficiency on the different cell populations of the cerebellum in the young rat.

21 January 2018

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The cholinergic system in developing cerebellum: comparative study of normal, hypothyroid and underfed rats.

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An appropriate model for congenital hypothyroidism in the rat induced by neonatal treatment with propylthiouracil and surgical thyroidectomy: studies on learning ability and biochemical parameters.

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Highly improved precision of the hypophysectomized female rat body weight gain bioassay for growth hormone by increased frequency of injections, avoidance of antibody formation, and other simple modifications.

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Stimulation of supranormal growth in prepubertal, adult plateaued, and hypophysectomized female rats by large doses of rat growth hormone: physiological effects and adverse consequences

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Regulation of postnatal intestinal maturation by growth hormone: studies in rats with isolated growth hormone deficiency

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Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation

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IGF-I and IGF-II expression in human breast cancer xenografts: relationship to hormone independence

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Human osteosarcoma (U-2 OS) cells express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptors and synthesize IGF-II: autocrine growth stimulation by IGF-II via the IGF-I re

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Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II.

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Type 1 IGF receptor in human breast diseases

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A test of evolutionary theories of senescence

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Evolution of senescence: late survival sacrificed for reproduction

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A conserved regulatory system for aging

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21 January 2018

Identifiers

DOI

10.1093/GERONA/57.5.B177

1 reference

3 August 2017

1 reference