Reduced sodium channel Na(v)1.1 levels in BACE1-null mice (Q34624269)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190943%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Reduced sodium channel Na(v)1.1 levels in BACE1-null mice (English)

1 reference

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19 January 2020

3

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19 January 2020

author name string

Doo Yeon Kim

series ordinal

1

1 reference

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19 January 2020

Manuel T Gersbacher

series ordinal

2

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19 January 2020

Dora M Kovacs

series ordinal

4

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19 January 2020

language of work or name

English

0 references

publication date

29 December 2010

1 reference

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Journal of Biological Chemistry

19 January 2020

published in

1 reference

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19 January 2020

volume

286

1 reference

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19 January 2020

issue

10

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19 January 2020

page(s)

8106-8116

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BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

19 January 2020

cites work

1 reference

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BACE1 deficiency causes altered neuronal activity and neurodegeneration

7 July 2018

1 reference

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NaV1.1 channels and epilepsy

7 July 2018

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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

7 July 2018

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Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

7 July 2018

1 reference

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Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis

7 July 2018

1 reference

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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

7 July 2018

1 reference

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Gamma-secretase inhibition and modulation for Alzheimer's disease

7 July 2018

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Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

7 July 2018

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BACE1 expression and activity: relevance in Alzheimer's disease

7 July 2018

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BACE1 regulates voltage-gated sodium channels and neuronal activity

7 July 2018

1 reference

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

7 July 2018

1 reference

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Control of peripheral nerve myelination by the beta-secretase BACE1

7 July 2018

1 reference

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Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy

7 July 2018

1 reference

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BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

7 July 2018

1 reference

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Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration

7 July 2018

1 reference

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beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

7 July 2018

1 reference

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Na+ channel expression along axons in multiple sclerosis and its models

7 July 2018

1 reference

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Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons

7 July 2018

1 reference

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Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger

7 July 2018

1 reference

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The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

7 July 2018

1 reference

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Overview of the voltage-gated sodium channel family

7 July 2018

1 reference

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Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits

7 July 2018

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

7 July 2018

1 reference

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The beta-secretase, BACE: a prime drug target for Alzheimer's disease

7 July 2018

1 reference

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Molecular mechanisms of gating and drug block of sodium channels

7 July 2018

1 reference

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Sodium channel beta subunits: anything but auxiliary

7 July 2018

1 reference

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From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

7 July 2018

1 reference

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

7 July 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

7 July 2018

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Treating the agitated Alzheimer patient

7 July 2018

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Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

7 July 2018

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The hippocampus in aging and Alzheimer's disease

7 July 2018

1 reference

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Biosynthesis and processing of the alpha subunit of the voltage-sensitive sodium channel in rat brain neurons

7 July 2018

1 reference

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Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain

7 July 2018

1 reference

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

7 July 2018

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alpha- and beta-secretase: profound changes in Alzheimer's disease.

21 January 2018

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

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Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

21 January 2018

1 reference

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Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134692

Molecular Mechanisms of Gating and Drug Block of Sodium Channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134692

Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134692

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134692

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134692

A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134692

Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134692

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134692

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134692

Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21190943

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.134692

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190943%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190943%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

21190943

1 reference