Spinning molecular immunology into successful immunotherapy (Q34632056)

3 August 2017

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title

Spinning molecular immunology into successful immunotherapy (English)

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3 August 2017

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Drew M Pardoll

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3 August 2017

1 April 2002

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Nature Reviews Immunology

3 August 2017

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3 August 2017

2

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3 August 2017

227-238

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3 August 2017

4

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Antigenic specificities on murine sarcoma cells. Reciprocal relationship between normal transplantation antigens (H-2) and tumor-specific immunogenicity

3 August 2017

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Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

21 January 2018

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Loss of HLA class-I alleles, heavy chains and β2-microglobulin in colorectal cancer

21 January 2018

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Identification of human cancers deficient in antigen processing

21 January 2018

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A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance

21 January 2018

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Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy

21 January 2018

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Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

21 January 2018

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Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy

21 January 2018

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The central role of CD4(+) T cells in the antitumor immune response

21 January 2018

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B cells inhibit induction of T cell-dependent tumor immunity.

21 January 2018

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

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Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan

21 January 2018

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Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens

21 January 2018

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Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the Nasopharynx

21 January 2018

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Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease

21 January 2018

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Dendritic cells and the control of immunity

21 January 2018

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Identification of proliferating dendritic cell precursors in mouse blood

21 January 2018

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Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified

21 January 2018

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Toll-like receptors: critical proteins linking innate and acquired immunity

21 January 2018

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Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

21 January 2018

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Activation of human dendritic cells through CD40 cross-linking.

21 January 2018

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

21 January 2018

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Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

21 January 2018

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Developmental regulation of MHC class II transport in mouse dendritic cells.

21 January 2018

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Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity

21 January 2018

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Dendritic cells infiltrating tumors cotransduced with granulocyte/macrophage colony-stimulating factor (GM-CSF) and CD40 ligand genes take up and present endogenous tumor-associated antigens, and prime naive mice for a cytotoxic T lymphocyte respons

21 January 2018

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Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma

21 January 2018

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Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells

21 January 2018

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Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

21 January 2018

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Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation

21 January 2018

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Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes

21 January 2018

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Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells

21 January 2018

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Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo

21 January 2018

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Equipotent generation of protective antitumor immunity by various methods of dendritic cell loading with whole cell tumor antigens

21 January 2018

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Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity

21 January 2018

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Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases

21 January 2018

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Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo

21 January 2018

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Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood.

21 January 2018

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Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines

21 January 2018

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The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments

21 January 2018

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Roles of heat-shock proteins in innate and adaptive immunity

21 January 2018

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Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96.

21 January 2018

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Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines and the effect of fever-range hyperthermia on vaccine activity

21 January 2018

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Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway

21 January 2018

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Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways

21 January 2018

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CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin

21 January 2018

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T-cell recognition of antigen. A process controlled by transient intermolecular interactions

21 January 2018

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Human tumor antigens recognized by T cells

21 January 2018

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Heteroclitic immunization induces tumor immunity

21 January 2018

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Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens

21 January 2018

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Improving vaccine potency through intercellular spreading and enhanced MHC class I presentation of antigen.

21 January 2018

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Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells

21 January 2018

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Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

21 January 2018

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Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?

21 January 2018

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Signaling through OX40 (CD134) breaks peripheral T-cell tolerance.

21 January 2018

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High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993

21 January 2018

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Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters

21 January 2018

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Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin

21 January 2018

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Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety

21 January 2018

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Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a murine tumor model

21 January 2018

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Immunization with type 5 adenovirus recombinant for a tumor antigen in combination with recombinant canarypox virus (ALVAC) cytokine gene delivery induces destruction of established prostate tumors

21 January 2018

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Virus subversion of immunity: a structural perspective

21 January 2018

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The prime-boost strategy: exciting prospects for improved vaccination

21 January 2018

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21 January 2018

Recombinant BCG vaccines

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Recent advances with recombinant bacterial vaccine vectors.

21 January 2018

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Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization

21 January 2018

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Oral somatic transgene vaccination using attenuated S. typhimurium.

21 January 2018

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CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy

21 January 2018

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Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accomp

21 January 2018

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CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.

21 January 2018

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B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

21 January 2018

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

21 January 2018

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B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells

21 January 2018

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

21 January 2018

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The T-cell protein tyrosine phosphatase

21 January 2018

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CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

21 January 2018

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Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor

21 January 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

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Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes

21 January 2018

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Human neoplasms elicit multiple specific immune responses in the autologous host

21 January 2018

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SSX: a multigene family with several members transcribed in normal testis and human cancer

21 January 2018

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

21 January 2018

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Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response

21 January 2018

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Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes.

21 January 2018

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A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

21 January 2018

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GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

21 January 2018

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Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction

21 January 2018

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

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Peripheral T cell tolerance as a tumor escape mechanism: deletion of CD4+ T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma

21 January 2018

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Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease

31 March 2020

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The dendritic cell system and its role in immunogenicity

31 March 2020

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Human CD14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4.

31 March 2020

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Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability

31 March 2020

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Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

31 March 2020

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Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells

31 March 2020

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Lentivirus-transduced human monocyte-derived dendritic cells efficiently stimulate antigen-specific cytotoxic T lymphocytes

31 March 2020

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Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells

31 March 2020

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Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations

31 March 2020

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A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides

31 March 2020

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HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

31 March 2020

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The role of heat shock protein (hsp70) in dendritic cell maturation: hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors

31 March 2020

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31 March 2020

Cancer Tumor antigens

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Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complex

31 March 2020

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Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors

31 March 2020

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Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines

31 March 2020

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Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes

31 March 2020

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Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

31 March 2020

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Engagement of the OX-40 receptor in vivo enhances antitumor immunity

31 March 2020

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Immunocytokines: a promising approach to cancer immunotherapy

31 March 2020

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Enhancing efficacy of recombinant anticancer vaccines with prime/boost regimens that use two different vectors

31 March 2020

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A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours

31 March 2020

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A K-ras 13Gly-->Asp mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?

31 March 2020

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p21-ras-peptide-specific T-cell responses in a patient with colorectal cancer. CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly-->Asp).

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI774

1 reference

release_ey3rvhujtva7xmsxaeag6stbv4

3 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ey3rvhujtva7xmsxaeag6stbv4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

12001994

1 reference

PubMed ID

12001994