Tracking T cells with tetramers: new tales from new tools (Q34632077)

3 August 2017

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title

Tracking T cells with tetramers: new tales from new tools (English)

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3 August 2017

1

Paul Klenerman

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3 August 2017

2

Vincenzo Cerundolo

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3 August 2017

3

P Rod Dunbar

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3 August 2017

publication date

1 April 2002

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

2

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3 August 2017

issue

4

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3 August 2017

page(s)

263-272

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HLA-peptide tetrameric complexes

3 August 2017

cites work

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31 March 2020

A new look at T cells

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Studies of human antiviral CD8+ lymphocytes using class I peptide tetramers

31 March 2020

1 reference

Dissecting the host response to a gamma-herpesvirus

31 March 2020

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Phenotypic analysis of antigen-specific T lymphocytes

31 March 2020

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Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

31 March 2020

1 reference

Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

31 March 2020

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Preferential localization of effector memory cells in nonlymphoid tissue

31 March 2020

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Virus-specific CD8+ T cells in primary and secondary influenza pneumonia

31 March 2020

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Measuring the diaspora for virus-specific CD8+ T cells.

31 March 2020

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CD8(+) T-cell selection, function, and death in the primary immune response in vivo

31 March 2020

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Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo

31 March 2020

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Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection.

31 March 2020

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Analysis of successful immune responses in persons infected with hepatitis C virus

31 March 2020

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CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained

31 March 2020

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Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection

31 March 2020

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CD8(+) lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: implications for vaccine design and testing

31 March 2020

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The liver as a site of T-cell apoptosis: graveyard, or killing field?

31 March 2020

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Simian immunodeficiency virus (SIV)-specific CTL are present in large numbers in livers of SIV-infected rhesus monkeys

31 March 2020

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Characteristics of virus-specific CD8(+) T cells in the liver during the control and resolution phases of influenza pneumonia

31 March 2020

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Viral immune evasion due to persistence of activated T cells without effector function

31 March 2020

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An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

31 March 2020

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Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors.

31 March 2020

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Direct ex vivo measurement of CD8(+) T-lymphocyte responses to human parvovirus B19.

31 March 2020

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Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood.

31 March 2020

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Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope

31 March 2020

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Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8+ T lymphocytes.

31 March 2020

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EBV-specific CD8+ T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function.

31 March 2020

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Skewed maturation of memory HIV-specific CD8 T lymphocytes

31 March 2020

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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

31 March 2020

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Priming of memory but not effector CD8 T cells by a killed bacterial vaccine

31 March 2020

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Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers

31 March 2020

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Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection

31 March 2020

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The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection

31 March 2020

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Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells

31 March 2020

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Determinants of viral clearance and persistence during acute hepatitis C virus infection

31 March 2020

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Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma

31 March 2020

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High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function

31 March 2020

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Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy.

31 March 2020

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31 March 2020

Cancer Tumor antigens

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Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

31 March 2020

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Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes

31 March 2020

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A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response

31 March 2020

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An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillanc

31 March 2020

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Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

31 March 2020

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A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3.

31 March 2020

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Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor

31 March 2020

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Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses.

31 March 2020

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Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy

31 March 2020

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Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

31 March 2020

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High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals

31 March 2020

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In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes

31 March 2020

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Mature dendritic cells prime functionally superior melan-A-specific CD8+ lymphocytes as compared with nonprofessional APC.

31 March 2020

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Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo.

31 March 2020

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High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo

31 March 2020

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Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo.

31 March 2020

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HLA-A2 Restricted, Melanocyte-Specific CD8+ T Lymphocytes Detected in Vitiligo Patients are Related to Disease Activity and are Predominantly Directed Against MelanA/MART1

31 March 2020

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Tumor-specific killer cells in paraneoplastic cerebellar degeneration

31 March 2020

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Clonal expansion of Melan A-specific cytotoxic T lymphocytes in a melanoma patient responding to continued immunization with melanoma-associated peptides

31 March 2020

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Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells

31 March 2020

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Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1

31 March 2020

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Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

31 March 2020

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Phase 2 trial of vaccination with tyrosinase peptides and granulocyte-macrophage colony-stimulating factor in patients with metastatic melanoma.

31 March 2020

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Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells

31 March 2020

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Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells.

31 March 2020

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Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cells

31 March 2020

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Status of activation of circulating vaccine-elicited CD8+ T cells

31 March 2020

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Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes

31 March 2020

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Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers

31 March 2020

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In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers

31 March 2020

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Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

31 March 2020

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Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants

31 March 2020

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HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells

31 March 2020

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Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers

31 March 2020

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MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen

31 March 2020

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Cutting edge: detection of antigen-specific CD4+ T cells by HLA-DR1 oligomers is dependent on the T cell activation state

31 March 2020

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Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography

31 March 2020

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Valpha24-JalphaQ-independent, CD1d-restricted recognition of alpha-galactosylceramide by human CD4(+) and CD8alphabeta(+) T lymphocytes.

31 March 2020

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Immunology taught by viruses

31 March 2020

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Immune control of HIV-1 after early treatment of acute infection

31 March 2020

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Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes

31 March 2020

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Cutting edge: lipid raft integrity affects the efficiency of MHC class I tetramer binding and cell surface TCR arrangement on CD8+ T cells

31 March 2020

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Critical role for CD8 in binding of MHC tetramers to TCR: CD8 antibodies block specific binding of human tumor-specific MHC-peptide tetramers to TCR.

31 March 2020

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Cutting edge: In situ tetramer staining of antigen-specific T cells in tissues

31 March 2020

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Discrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life

31 March 2020

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Rapid effector function in CD8+ memory T cells

31 March 2020

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HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

31 March 2020

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Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children

31 March 2020

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Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice.

31 March 2020

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Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia

31 March 2020

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Virus-specific and bystander CD8+ T-cell proliferation in the acute and persistent phases of a gammaherpesvirus infection

31 March 2020

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Coordinate regulation of complex T cell populations responding to bacterial infection.

31 March 2020

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CD8+ cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: correlation with time from transplant to receipt of tacrolimus

31 March 2020

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Characterization of CMVpp65-specific CD8+ T lymphocytes using MHC tetramers in kidney transplant patients and healthy participants

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI777

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3 August 2017

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