Altered renal FGF23-mediated activity involving MAPK and Wnt: effects of the Hyp mutation (Q34632352)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675303%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Altered renal FGF23-mediated activity involving MAPK and Wnt: effects of the Hyp mutation (English)

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9 February 2020

5

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9 February 2020

author name string

Emily G Farrow

1

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9 February 2020

Lelia J Summers

2

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9 February 2020

Susan C Schiavi

3

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9 February 2020

James A McCormick

4

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9 February 2020

Kenneth E White

6

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9 February 2020

language of work or name

English

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publication date

30 July 2010

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9 February 2020

published in

Journal of Endocrinology

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9 February 2020

volume

207

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9 February 2020

issue

1

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9 February 2020

page(s)

67-75

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Treatment of X-linked hypophosphatemia with calcitriol and phosphate increases circulating fibroblast growth factor 23 concentrations

9 February 2020

cites work

1 reference

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Novel regulators of Fgf23 expression and mineralization in Hyp bone

7 July 2018

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Initial FGF23-mediated signaling occurs in the distal convoluted tubule

7 July 2018

1 reference

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Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression

7 July 2018

1 reference

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Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development

7 July 2018

1 reference

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FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis

7 July 2018

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A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

7 July 2018

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

7 July 2018

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Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades

7 July 2018

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Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism

7 July 2018

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Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.

7 July 2018

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Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway

7 July 2018

1 reference

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Basic fibroblast growth factor activates ERK and induces c-fos in human embryonic stem cell line MizhES1.

7 July 2018

1 reference

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Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice

7 July 2018

1 reference

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FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

7 July 2018

1 reference

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Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

7 July 2018

1 reference

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Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX.

7 July 2018

1 reference

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Involvement of the MAPK-kinase pathway in the PTH-mediated regulation of the proximal tubule type IIa Na+/Pi cotransporter in mouse kidney

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050595

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050595

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

7 July 2018

1 reference

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The polycystic kidney disease 1 gene product modulates Wnt signaling

7 July 2018

1 reference

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11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules.

7 July 2018

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Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

7 July 2018

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A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

7 July 2018

1 reference

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Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23.

7 July 2018

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Pathogenic role of Fgf23 in Hyp mice.

26 October 2018

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Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis

26 October 2018

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FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa.

26 October 2018

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Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice

26 October 2018

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Serum FGF23 levels in normal and disordered phosphorus homeostasis.

26 October 2018

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Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia

26 October 2018

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Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry

26 October 2018

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12 December 2020

Induction of kidney epithelial morphogenesis by cells expressing Wnt-1

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12 December 2020

Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways

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12 December 2020

beta-catenin expression and mutational analysis in renal cell carcinomas

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12 December 2020

The efficacy of vitamin D2 and oral phosphorus therapy in X-linked hypophosphatemic rickets and osteomalacia

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12 December 2020

Identifiers

DOI

10.1677/JOE-10-0181

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675303%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675303%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference