SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change (Q34636554)

3 August 2017

SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change (English)

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single-nucleotide polymorphism

3 August 2017

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James C Whisstock

11

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author name string

David J Askew

1

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3 August 2017

Sule Cataltepe

2

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3 August 2017

Vasantha Kumar

3

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3 August 2017

Christopher Edwards

4

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3 August 2017

Serena M Pace

5

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3 August 2017

Rica N Howarth

6

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3 August 2017

Stephen C Pak

7

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3 August 2017

Yuko S Askew

8

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3 August 2017

Dieter Brömme

9

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3 August 2017

Cliff J Luke

10

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3 August 2017

Gary A Silverman

12

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3 August 2017

language of work or name

English

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publication date

11 June 2007

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Journal of Biological Chemistry

3 August 2017

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3 August 2017

282

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3 August 2017

34

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3 August 2017

24948-24960

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Serpin structure, mechanism, and function

3 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

An overview of the serpin superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

The molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Structural mechanism for the carriage and release of thyroxine in the blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Effects of mutations in the hinge region of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Nonsense-mediated mRNA decay in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

A novel missense mutation in the antithrombin III gene (Ser349----Pro) causing recurrent venous thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

An atlas of serpin conformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Ovalbumin and angiotensinogen lack serpin S-R conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

The International HapMap Project

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

A haplotype map of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Mutation of the Highly Conserved Tryptophan in the Serpin Breach Region Alters the Inhibitory Mechanism of Plasminogen Activator Inhibitor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

What do dysfunctional serpins tell us about molecular mobility and disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Serpin conformational change in ovalbumin. Enhanced reactive center loop insertion through hinge region mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

21 January 2018

The Protein Data Bank

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Crystal structure of ovalbumin as a model for the reactive centre of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Maspin plays an essential role in early embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

The role of interleukin-4 and interleukin-13 in the non-immunologic aspects of asthma pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Analysis of novel disease-related genes in bronchial asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

Comparison of Human Chromosome 6p25 with Mouse Chromosome 13 Reveals a Greatly Expanded Ov-Serpin Gene Repertoire in the Mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703182200

21 January 2018

Identifiers

DOI

10.1074/JBC.M703182200

1 reference

3 August 2017

1 reference