Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study (Q34652628)

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English	Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study	scientific article

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study (English)

1 reference

Europe PubMed Central

3 August 2017

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metastatic melanoma

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

Caroline Robert

1

object named as

Caroline Robert

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object named as

Ana Arance

7

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object named as

Paul Lorigan

4

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Dirk Schadendorf

9

object named as

Dirk Schadendorf

1 reference

Europe PubMed Central

3 August 2017

Reinhard Dummer

2

object named as

Reinhard Dummer

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Europe PubMed Central

3 August 2017

author name string

Ralf Gutzmer

3

1 reference

Europe PubMed Central

3 August 2017

Kevin B Kim

5

1 reference

Europe PubMed Central

3 August 2017

Marta Nyakas

6

1 reference

Europe PubMed Central

3 August 2017

Gabriella Liszkay

8

1 reference

Europe PubMed Central

3 August 2017

Mireille Cantarini

10

1 reference

Europe PubMed Central

3 August 2017

Stuart Spencer

11

1 reference

Europe PubMed Central

3 August 2017

Mark R Middleton

12

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Europe PubMed Central

3 August 2017

publication date

2 June 2013

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Europe PubMed Central

3 August 2017

Lancet Oncology Commission

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Europe PubMed Central

3 August 2017

14

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Europe PubMed Central

3 August 2017

8

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Europe PubMed Central

3 August 2017

733-740

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Europe PubMed Central

3 August 2017

Incidence of BRAF p.Val600Glu and p.Val600Lys mutations in a consecutive series of 183 metastatic melanoma patients from a high incidence region

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2813%2970237-7

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

1 reference

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GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition

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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

1 reference

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MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study

1 reference

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Improved survival with MEK inhibition in BRAF-mutated melanoma

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Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

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Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma

1 reference

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The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel

1 reference

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Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

1 reference

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based on heuristic

inferred from DOI database lookup

The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

1 reference

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Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)

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Analysis of duration of response in oncology trials

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Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor

1 reference

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7 January 2021

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Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

1 reference

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7 January 2021

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Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2813%2970237-7

7 January 2021

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Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial

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Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma

1 reference

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A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer

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Mitogen-activated protein/extracellular signal-regulated kinase kinase inhibition results in biphasic alteration of epidermal homeostasis with keratinocytic apoptosis and pigmentation disorders.

1 reference

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Resistance to BRAF-targeted therapy in melanoma

1 reference

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Resistance patterns with tyrosine kinase inhibitors in melanoma: new insights

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2813%2970237-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2813%2970237-7

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Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.

1 reference

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Identifiers

10.1016/S1470-2045(13)70237-7

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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