Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression (Q34655177)

3 August 2017

Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression (English)

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3 August 2017

Alejandro Villagra

1

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3 August 2017

Natalia Ulloa

2

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3 August 2017

Xiaohong Zhang

3

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3 August 2017

Zhigang Yuan

4

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3 August 2017

Eduardo Sotomayor

5

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3 August 2017

Edward Seto

6

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3 August 2017

language of work or name

English

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publication date

9 October 2007

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Journal of Biological Chemistry

3 August 2017

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3 August 2017

282

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3 August 2017

49

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3 August 2017

35457-35470

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Regulation of the mevalonate pathway

3 August 2017

1 reference

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

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Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

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Cholesterol homeostasis: clipping out a slippery regulator

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Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes

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Inborn errors of sterol biosynthesis

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Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library

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Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat

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Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase

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Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

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The histone deacetylase-3 complex contains nuclear receptor corepressors

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Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3.

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Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity

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Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

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Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family

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Current perspectives on statins

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Cholesterol-independent effects of statins and new therapeutic targets: ischemic stroke and dementia

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Statins and cancer development.

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Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity

21 January 2018

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Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation

21 January 2018

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Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein

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Conditional response of the human steroidogenic acute regulatory protein gene promoter to sterol regulatory element binding protein-1a

21 January 2018

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YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes

21 January 2018

1 reference

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Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?

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Transcription factor YY1 functions as a PcG protein in vivo

21 January 2018

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The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing.

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Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein

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Characterization of FIII/YY1, a Xenopus laevis conserved zinc-finger protein binding to the first exon of L1 and L14 ribosomal protein genes

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Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

21 January 2018

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The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor

21 January 2018

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Requirement of histone deacetylase activity for signaling by STAT1.

21 January 2018

1 reference

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Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation

21 January 2018

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Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1.

21 January 2018

1 reference

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Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression

21 January 2018

1 reference

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Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation

21 January 2018

1 reference

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The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene

21 January 2018

1 reference

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The human lanosterol synthase gene maps to chromosome 21q22.3

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M701719200

1 reference

3 August 2017

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