Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. (Q34655877)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18318466%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors (English)

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3 January 2020

9

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3 January 2020

author name string

Sanjeev Kumar

1

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3 January 2020

William P Malachowski

2

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3 January 2020

James B DuHadaway

3

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3 January 2020

Judith M LaLonde

4

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3 January 2020

Patrick J Carroll

5

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3 January 2020

Daniel Jaller

6

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3 January 2020

Richard Metz

7

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3 January 2020

George C Prendergast

8

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3 January 2020

language of work or name

English

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publication date

5 March 2008

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Journal of Medicinal Chemistry

3 January 2020

published in

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3 January 2020

volume

51

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3 January 2020

issue

6

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3 January 2020

page(s)

1706-1718

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Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

3 January 2020

cites work

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Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses

7 July 2018

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Exiguamine A, an indoleamine-2,3-dioxygenase (IDO) inhibitor isolated from the marine sponge Neopetrosia exigua

7 July 2018

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7 July 2018

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7 July 2018

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Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

7 July 2018

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Menadione is a metabolite of oral vitamin K.

7 July 2018

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Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.

7 July 2018

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Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors.

7 July 2018

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Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.

7 July 2018

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Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy

7 July 2018

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IDO expression by dendritic cells: tolerance and tryptophan catabolism

7 July 2018

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Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.

7 July 2018

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Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific

7 July 2018

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Activation and detoxification of naphthoquinones by NAD(P)H: quinone oxidoreductase

7 July 2018

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Quinones and glutathione metabolism.

7 July 2018

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Force fields for protein simulations

7 July 2018

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The anticancer effects of vitamin K.

7 July 2018

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Improved protein-ligand docking using GOLD

7 July 2018

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Structure validation by Calpha geometry: phi,psi and Cbeta deviation

7 July 2018

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Cancer immunoediting: from immunosurveillance to tumor escape

7 July 2018

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Heme-Containing Oxygenases

7 July 2018

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Asparagine and glutamine: using hydrogen atom contacts in the choice of side-chain amide orientation

7 July 2018

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Development and validation of a genetic algorithm for flexible docking

7 July 2018

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Inhibition of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by beta-carboline and indole derivatives

7 July 2018

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Catalysis, binding and enzyme-substrate complementarity.

7 July 2018

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One-electron reduction of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents.

7 July 2018

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Streptonigrin. 1. Structure-activity relationships among simple bicyclic analogues. Rate dependence of DNA degradation on quinone reduction potential.

7 July 2018

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Enzyme kinetic and spectroscopic studies of inhibitor and effector interactions with indoleamine 2,3-dioxygenase. 1. Norharman and 4-phenylimidazole binding to the enzyme as inhibitors and heme ligands

7 July 2018

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Effects of tryptophan and pH on the kinetics of superoxide radical binding to indoleamine 2,3-dioxygenase studied by pulse radiolysis

7 July 2018

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New colorimetric cytotoxicity assay for anticancer-drug screening

7 July 2018

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1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

7 July 2018

1 reference

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Exogenous glutathione protects endothelial cells from menadione toxicity

7 July 2018

1 reference

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Indoleamine 2,3-dioxygenase. Potassium superoxide as substrate

7 July 2018

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The one-electron transfer redox potentials of free radicals. I. The oxygen/superoxide system

7 July 2018

1 reference

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A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase

7 July 2018

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Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.

26 October 2018

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Electronic effects of electron-donating and -withdrawing groups in model complexes for iron-tyrosine-containing metalloenzymes

26 October 2018

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Vitamins K2, K3 and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules.

26 October 2018

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Biomimetic synthesis of antimalarial naphthoquinones

26 October 2018

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Menadione causes endothelial barrier failure by a direct effect on intracellular thiols, independent of reactive oxidant production

26 October 2018

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Quantitation of tryptophan, kynurenine and kynurenic acid in human plasma by capillary liquid chromatography-electrospray ionization tandem mass spectrometry

26 October 2018

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More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC.

26 October 2018

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Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants.

26 October 2018

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Expression and purification of recombinant human indoleamine 2, 3-dioxygenase

26 October 2018

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Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents.

26 October 2018

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Loss of metastatic and primary tumor factor X activator capabilities by Lewis lung carcinoma cells cultured in vitamin K-dependent protein deficient serum

26 October 2018

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12 December 2020

Indoleamine 2,3-dioxygenase. Equilibrium studies of the tryptophan binding to the ferric, ferrous, and CO-bound enzymes

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12 December 2020

Interaction of menadione (2-methyl-1,4-naphthoquinone) with glutathione

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12 December 2020

Interactions between nitric oxide and indoleamine 2,3-dioxygenase

1 reference

12 December 2020

Stereobiochemical aspects of warfarin isomers for inhibition of enzymatic alkylation of menaquinone-0 to menaquinone-4 in chick liver

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12 December 2020

Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients

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12 December 2020

Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells

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12 December 2020

Metabolism of menadione-6,7-3H in the rat

1 reference

12 December 2020

STUDIES ON QUINONE-THIOETHERS. I. MECHANISM OF FORMATION AND PROPERTIES OF THIODIONE

1 reference

12 December 2020

The apparent inhibition of superoxide dismutase activity by quinones

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12 December 2020

Pilzfarbstoffe, 53. Vesparion, ein Naphtho[2,3-b]pyrandion-Derivat aus dem SchleimpilzMetatrichia vesparium (Myxomycetes)

1 reference

COCI

https://opencitations.net/index/api/v1/citations/10.1002/JLAC.198719870830

9 March 2024

Identifiers

DOI

10.1021/JM7014155

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18318466%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18318466%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

18318466

1 reference