Cannabidiol in humans-the quest for therapeutic targets (Q34657897)

3 August 2017

Cannabidiol in humans-the quest for therapeutic targets (English)

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3 August 2017

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Simon Zhornitsky

1

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author name string

Stéphane Potvin

series ordinal

2

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3 August 2017

21 May 2012

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3 August 2017

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3 August 2017

5

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3 August 2017

5

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3 August 2017

529-552

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Creative Commons Attribution 4.0 International

3 August 2017

start time

21 May 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.

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The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.

7 July 2018

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Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.

7 July 2018

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Modulation of auditory and visual processing by delta-9-tetrahydrocannabinol and cannabidiol: an FMRI study

7 July 2018

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Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients

7 July 2018

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Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

7 July 2018

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Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

7 July 2018

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Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

7 July 2018

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Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report

7 July 2018

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Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists

7 July 2018

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Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology

7 July 2018

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Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo

7 July 2018

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Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain

7 July 2018

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Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels

7 July 2018

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Cannabidiol: a promising drug for neurodegenerative disorders?

7 July 2018

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The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function

7 July 2018

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5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats

7 July 2018

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Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing

7 July 2018

1 reference

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Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

7 July 2018

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Inhibition of recombinant human T-type calcium channels by Delta9-tetrahydrocannabinol and cannabidiol

7 July 2018

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5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid.

7 July 2018

1 reference

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The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition

7 July 2018

1 reference

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The orphan receptor GPR55 is a novel cannabinoid receptor

7 July 2018

1 reference

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The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin

7 July 2018

1 reference

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Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain

7 July 2018

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Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the C

7 July 2018

1 reference

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Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

7 July 2018

1 reference

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History of cannabis as a medicine: a review

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Agonistic properties of cannabidiol at 5-HT1a receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Chemical constituents of marijuana: the complex mixture of natural cannabinoids

7 July 2018

1 reference

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Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids.

7 July 2018

1 reference

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Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Effects of cannabidiol (CBD) on regional cerebral blood flow

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

The effects of cannabinoids on the brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Hypnotic and antiepileptic effects of cannabidiol.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Evidence that cannabidiol does not significantly alter the pharmacokinetics of tetrahydrocannabinol in man

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Anticonvulsant properties of cannabidiol

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

The effect of cannabinoids on intestinal motility and their antinociceptive effect in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Cannabidiol interferes with the effects of Δ9-tetrahydrocannabinol in man

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Controlled clinical trial of cannabidiol in Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Cannabidiol--antiepileptic drug comparisons and interactions in experimentally induced seizures in rats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Influence of cannabidiol on delta-9-tetrahydrocannabinol effects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Interaction of cannabidiol and alcohol in humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews.

7 July 2018

1 reference

Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract

21 January 2018

1 reference

Simultaneous and sensitive analysis of THC, 11-OH-THC, THC-COOH, CBD, and CBN by GC-MS in plasma after oral application of small doses of THC and cannabis extract

21 January 2018

1 reference

Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes

21 January 2018

1 reference

Comparison in the In Vitro Inhibitory Effects of Major Phytocannabinoids and Polycyclic Aromatic Hydrocarbons Contained in Marijuana Smoke on Cytochrome P450 2C9 Activity

21 January 2018

1 reference

(-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens

21 January 2018

1 reference

Distribution and characterization of anandamide amidohydrolase in mouse brain and liver.

21 January 2018

1 reference

Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibition

21 January 2018

1 reference

Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol

21 January 2018

1 reference

The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects

21 January 2018

1 reference

Different effects of nabilone and cannabidiol on binocular depth inversion in Man.

21 January 2018

1 reference

Acute effects of Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativity

21 January 2018

1 reference

Effects of acute oral Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory P300 event-related potential in healthy volunteers

21 January 2018

1 reference

Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects

21 January 2018

1 reference

S39-02 Antipsychotic effects of cannabidiol

21 January 2018

1 reference

Cannabidiol monotherapy for treatment-resistant schizophrenia

21 January 2018

1 reference

Cannabidiol was ineffective for manic episode of bipolar affective disorder.

21 January 2018

1 reference

Performance of schizophrenic patients in the Stroop Color Word Test and electrodermal responsiveness after acute administration of cannabidiol (CBD).

21 January 2018

1 reference

Safety, tolerability, and efficacy of orally administered cannabinoids in MS.

21 January 2018

1 reference

Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies

21 January 2018

1 reference

The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors.

21 January 2018

1 reference

Cannabidiol injected into the bed nucleus of the stria terminalis reduces the expression of contextual fear conditioning via 5-HT1A receptors.

21 January 2018

1 reference

Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors

21 January 2018

1 reference

Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids

21 January 2018

1 reference

Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats

21 January 2018

1 reference

Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects

21 January 2018

1 reference

Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder

21 January 2018

1 reference

Effects of the cannabinoid receptor ligands on anxiety-related effects of d-amphetamine and nicotine in the mouse elevated plus maze test.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763649

The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS)

26 October 2018

1 reference

Effect of cannabidiol on plasma prolactin, growth hormone and cortisol in human volunteers

21 January 2018

1 reference

12 December 2020

Chronic administration of cannabidiol to healthy volunteers and epileptic patients

1 reference

12 December 2020

Metabolites of cannabidiol identified in human urine

1 reference

12 December 2020

Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety

1 reference

12 December 2020

Interaction between cannabidiol (CBD) and ∆(9)-tetrahydrocannabinol (THC): influence of administration interval and dose ratio between the cannabinoids

1 reference

12 December 2020

Effects of ipsapirone and cannabidiol on human experimental anxiety

1 reference

12 December 2020

Effect of cannabinoids on the abdominal constriction response in mice: within cannabinoid interactions

1 reference

12 December 2020

Cannabidiol and cannabinol in man

1 reference

12 December 2020

Interactions in man of delta-9-tetrahydrocannabinol; II. Cannabinol and cannabidiol

1 reference

12 December 2020

Identifiers

DOI

10.3390/PH5050529

1 reference

3 August 2017

1 reference

3 August 2017

1 reference

PubMed ID

24281562