Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress (Q34658022)

3 August 2017

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title

Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress (English)

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3 August 2017

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Jay W Heinecke

1

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3 August 2017

1 June 2002

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Free Radical Biology and Medicine

3 August 2017

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3 August 2017

32

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3 August 2017

11

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3 August 2017

1090-1101

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Koch's postulates for cholesterol

3 August 2017

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Role of oxidized low density lipoprotein in atherogenesis

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

The role of lipid peroxidation and antioxidants in oxidative modification of LDL.

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

The role of oxidized lipoproteins in atherogenesis

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Clinical trials of antioxidants in atherosclerosis: are we doing the right thing?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Antioxidants and atherosclerotic heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Is the emperor wearing clothes? Clinical trials of vitamin E and the LDL oxidation hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Antioxidant defenses and lipid peroxidation in human blood plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Alpha-tocopherol does not inhibit hypochlorite-induced oxidation of apolipoprotein B-100 of low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Increased atherosclerosis in myeloperoxidase-deficient mice

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Artifact-free quantification of free 3-chlorotyrosine, 3-bromotyrosine, and 3-nitrotyrosine in human plasma by electron capture-negative chemical ionization gas chromatography mass spectrometry and liquid chromatography-electrospray ionization tande

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Protein oxidation and aging

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

NADPH oxidase of neutrophils elevates o,o'-dityrosine cross-links in proteins and urine during inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Intact human ceruloplasmin oxidatively modifies low density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Role of endogenous ceruloplasmin in low density lipoprotein oxidation by human U937 monocytic cells

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Prooxidant iron and copper, with ferroxidase and xanthine oxidase activities in human atherosclerotic material.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Transition metal ions within human atherosclerotic lesions can catalyse the oxidation of low density lipoprotein by macrophages

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

THE SPECIFIC BINDING OF IRON(III) AND COPPER(II) TO TRANSFERRIN AND CONALBUMIN

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

The influence of medium components on Cu(2+)-dependent oxidation of low-density lipoproteins and its sensitivity to superoxide dismutase

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

The Biology of Oxygen Radicals

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Are body iron stores related to the risk of coronary heart disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Effect of iron overload and iron deficiency on atherosclerosis in the hypercholesterolemic rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Iron overload diminishes atherosclerosis in apoE-deficient mice

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Chronic hyperglycemia increases arterial low-density lipoprotein metabolism and atherosclerosis in cynomolgus monkeys

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Protein Aging by Carboxymethylation of Lysines Generates Sites for Divalent Metal and Redox Active Copper Binding: Relevance to Diseases of Glycoxidative Stress

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Free radicals generated during the glycation reaction of amino acids by methylglyoxal. A model study of protein-cross-linked free radicals

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Oxidation-reduction properties of methylglyoxal-modified protein in relation to free radical generation

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Oxidative chemistry of peroxynitrite

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Action of nitric oxide as an antioxidant against oxidation of soybean phosphatidylcholine liposomal membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Is NO an endogenous antiatherogenic molecule?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

L-arginine prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Oxygen Metabolism and the Toxic Properties of Phagocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Leukocytic oxygen activation and microbicidal oxidative toxins

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https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Human neutrophils employ chlorine gas as an oxidant during phagocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Electron paramagnetic resonance detection of free tyrosyl radical generated by myeloperoxidase, lactoperoxidase, and horseradish peroxidase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Higher oxidation states of prostaglandin H synthase. EPR study of a transient tyrosyl radical in the enzyme during the peroxidase reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fibroblasts and macrophage foam cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Brominating oxidants generated by human eosinophils

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Association between myeloperoxidase levels and risk of coronary artery disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Formation of nitrating and chlorinating species by reaction of nitrite with hypochlorous acid. A novel mechanism for nitric oxide-mediated protein modification

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

8-Nitro-2'-deoxyguanosine, a specific marker of oxidation by reactive nitrogen species, is generated by the myeloperoxidase-hydrogen peroxide-nitrite system of activated human phagocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsatu

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Modification of low density lipoprotein with 4-hydroxynonenal induces uptake by macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Scavenger receptor-independent stimulation of cholesterol esterification in macrophages by low density lipoprotein extracted from human aortic intima

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Mechanism of uptake of copper-oxidized low density lipoprotein in macrophages is dependent on its extent of oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Phagocytes and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Human phagocytes employ the myeloperoxidase-hydrogen peroxide system to synthesize dityrosine, trityrosine, pulcherosine, and isodityrosine by a tyrosyl radical-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Production of brominating intermediates by myeloperoxidase. A transhalogenation pathway for generating mutagenic nucleobases during inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico

1 reference

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7 January 2021

Vitamin E supplementation and cardiovascular events in high-risk patients

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Collaborative Group of the Primary Prevention Project

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Effects of vitamin E on lipid peroxidation in healthy persons

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

Molecular action of vitamin E in lipoprotein oxidation: implications for atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900792-X

7 January 2021

10.1016/S0891-5849(02)00792-X

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

12031894