The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production (Q34658539)

3 August 2017

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title

The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production (English)

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3 August 2017

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Kenneth Kaushansky

1

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3 August 2017

Jonathan G Drachman

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 May 2002

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3 August 2017

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3 August 2017

volume

21

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3 August 2017

issue

21

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3 August 2017

page(s)

3359-3367

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Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

Thrombocytopenia with absent radii: frequency of marrow megakaryocyte progenitors, proliferative characteristics, and megakaryocyte growth and development factor responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Thrombopoietin levels in patients with primary and reactive thrombocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Pharmacokinetics and hematological effects of the PEGylated thrombopoietin peptide mimetic GW395058 in rats and monkeys after intravenous or subcutaneous administration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Thrombopoietin signal transduction requires functional JAK2, not TYK2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Use of PEG-rHuMGDF in platelet engraftment after autologous stem cell transplantation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Aetiology and clinical significance of thrombocytosis: analysis of 732 patients with an elevated platelet count

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Optimization of retroviral gene transfer protocol to maintain the lymphoid potential of progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Thrombopoietin activates the growth of megakaryoblasts in patients with chronic myeloproliferative disorders and myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Circulating levels of thrombopoietic and inflammatory cytokines in patients with clonal and reactive thrombocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

1 reference

7 January 2021

A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Circulating thrombopoietin level in chronic immune thrombocytopenic purpura

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Gene transfer into baboon repopulating cells: A comparison of Flt-3 Ligand and megakaryocyte growth and development factor versus IL-3 during ex vivo transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Thrombopoietin therapy increases platelet yields in healthy platelet donors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

The glycan domain of thrombopoietin enhances its secretion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Megakaryopoiesis in vitro in myelodysplastic syndromes and acute myeloid leukaemia: effect of pegylated recombinant human megakaryocyte growth and development factor in combination with other growth factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Structure and transcription of the human c-mpl gene (MPL)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Functional analysis of the C-terminal region of recombinant human thrombopoietin. C-terminal region of thrombopoietin is a "shuttle" peptide to help secretion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Thrombopoietin induces activation of at least two distinct signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Thrombopoietin induces tyrosine phosphorylation of a common beta subunit of GM-CSF receptor and its association with Stat5 in TF-1/TPO cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Jak2 is essential for signaling through a variety of cytokine receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Identification of functionally important residues of human thrombopoietin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Thrombopoietic cytokines and reversal of thrombocytopenia after liver transplantation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Ex vivo expansion of cord blood progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Erythropoietin receptor activation by a ligand-induced conformation change

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase calpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Mutational screening of thrombopoietin receptor gene (c-mpl) in patients with congenital thrombocytopenia and absent radii (TAR).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Mobilization of primitive haemopoietic progenitor cells and stem cells with long-term repopulating ability into peripheral blood in mice by pegylated recombinant human megakaryocyte growth and development factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Thrombopoietin serum concentration in patients with reactive and myeloproliferative thrombocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Expression of c-mpl mRNA, the receptor for thrombopoietin, in acute myeloid leukemia blasts identifies a group of patients with poor response to intensive chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Recombinant human thrombopoietin (rhTPO) after autologous bone marrow transplantation: a phase I pharmacokinetic and pharmacodynamic study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Small peptides as potent mimetics of the protein hormone erythropoietin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205323

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205323

1 reference

Dimensions Publication ID

3 August 2017

1009611404

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1 reference