RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. (Q34660473)

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English	RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.	scientific article

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29 January 2020

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation (English)

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29 January 2020

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29 January 2020

Burkhard Becher

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Burkhard Becher

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29 January 2020

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Laura Codarri

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29 January 2020

Gabor Gyülvészi

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29 January 2020

Vinko Tosevski

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29 January 2020

Lysann Hesske

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29 January 2020

Adriano Fontana

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29 January 2020

Laurent Magnenat

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24 April 2011

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29 January 2020

Nature Immunology

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29 January 2020

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29 January 2020

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29 January 2020

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29 January 2020

APC-derived cytokines and T cell polarization in autoimmune inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

IL-23: changing the verdict on IL-12 function in inflammation and autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Th17 and regulatory T cells in mediating and restraining inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

EAE mediated by a non-IFN-γ/non-IL-17 pathway

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis.

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

Rapid ex vivo isolation and long-term culture of human Th17 cells

1 reference

https://api.crossref.org/works/10.1038%2FNI.2027

21 January 2018

IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passive induction of experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21516112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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