Nitrones, their value as therapeutics and probes to understand aging (Q34667181)

3 August 2017

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title

Nitrones, their value as therapeutics and probes to understand aging (English)

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3 August 2017

Robert A Floyd

1

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3 August 2017

Kenneth Hensley

2

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3 August 2017

Michael J Forster

3

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3 August 2017

Judith A Kelleher-Andersson

4

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3 August 2017

Paul L Wood

5

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3 August 2017

1 April 2002

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Mechanisms of Ageing and Development

3 August 2017

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3 August 2017

123

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3 August 2017

8

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3 August 2017

1021-1031

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N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Oxygen free radical involvement in ischemia and reperfusion injury to brain

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

alpha-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Excretion, metabolism and tissue distribution of a spin trapping agent, alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

The Free Radical Trapping Agent N-Tert.-Butyl-α-Phenylnitrone (PBN) Attenuates Cerebral Ischaemic Injury in Gerbils

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

The spin-trap N-tert-alpha-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Cochlear protection from carbon monoxide exposure by free radical blockers in the guinea pig.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Age influence on oxidative events during brain ischemia/reperfusion.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

p38 kinase is activated in the Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Inducible nitric oxide synthase gene expression in brain following cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Pharmacologic properties of phenyl N-tert-butylnitrone

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN).

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Phenyl N-tert-butylnitrone provides protection from endotoxin shock through amplified production of the anti-inflammatory cytokine interleukin-10

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Spin trapping agent, phenyl N-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Phenyl-T-butyl-nitrone is active against traumatic shock in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Effects of the spin trap-alpha-phenyl-N-tert-butyl nitrone (PBN) in transient forebrain ischaemia in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Ischemia-reperfusion induced acute renal failure in the rat is ameliorated by the spin-trapping agent alpha-phenyl-N-tert-butyl nitrone (PBN)

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-alpha-phenylnitrone (PBN).

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Antioxidant treatment with phenyl-alpha-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl N-tert-butylnitrone (PBN)

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Oxidative stress and cell cycle checkpoint function.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Phenyl-N-tert-butylnitrone demonstrates broad-spectrum inhibition of apoptosis-associated gene expression in endotoxin-treated rats

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Inhibition of the cytokine-mediated inducible nitric oxide synthase expression in rat insulinoma cells by phenyl N-tert-butylnitrone

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900385-2

7 January 2021

10.1016/S0047-6374(01)00385-2

Identifiers

DOI

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3 August 2017

1 reference