Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1) (Q34669224)

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20 January 2020

title

Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1) (English)

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20 January 2020

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5beta-dihydrocorticosterone

86384

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86381

5beta-dihydroaldosterone

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5beta-dihydroepitestosterone

86389

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17beta-hydroxy-5beta-estran-3-one

87331

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3

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20 January 2020

author name string

Mo Chen

series ordinal

1

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20 January 2020

Jason E Drury

series ordinal

2

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20 January 2020

publication date

19 January 2011

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20 January 2020

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20 January 2020

volume

76

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20 January 2020

issue

5

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20 January 2020

page(s)

484-490

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Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice

20 January 2020

cites work

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Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex

7 July 2018

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Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition

7 July 2018

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The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism

7 July 2018

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Crystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis

7 July 2018

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Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms

7 July 2018

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Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens

7 July 2018

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5 Beta-dihydroprogesterone and steroid 5 beta-reductase decrease in association with human parturition at term.

7 July 2018

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5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor.

7 July 2018

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Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin.

7 July 2018

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Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme.

7 July 2018

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

7 July 2018

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

7 July 2018

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Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase

7 July 2018

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Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases

7 July 2018

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Comparative anatomy of the aldo-keto reductase superfamily

7 July 2018

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Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

7 July 2018

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Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme

7 July 2018

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Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme

7 July 2018

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Stimulation of hemoglobin synthesis in chick blastoderms by certain 5beta androstane and 5beta pregnane steroids

7 July 2018

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Steroid control of porphyrin and heme biosynthesis: a new biological function of steroid hormone metabolites

7 July 2018

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

7 July 2018

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An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications

7 July 2018

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7 July 2018

Bile acid biosynthesis

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Human Delta4-3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism

7 July 2018

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Plant progesterone 5beta-reductase is not homologous to the animal enzyme. Molecular evolutionary characterization of P5betaR from Digitalis purpurea.

26 October 2018

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Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes

26 October 2018

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Dissection of the physiological interconversion of 5alpha-DHT and 3alpha-diol by rat 3alpha-HSD via transient kinetics shows that the chemical step is rate-determining: effect of mutating cofactor and substrate-binding pocket residues on catalysis

26 October 2018

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Possible endogenous regulators of steroid inactivating enzymes and glucocorticoid-induced Na+ retention.

26 October 2018

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An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone

26 October 2018

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12 December 2020

Conversion of cholesterol to bile acids in rat: purification and properties of a delta-4-3-ketosteroid 5-beta-reductase and a 3-alpha-hydroxysteroid dehydrogenase

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12 December 2020

Disorders of androgen action

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12 December 2020

Human hepatic cortisol reductase activities: enzymatic properties and substrate specificities of cytosolic cortisol delta 4-5 beta-reductase and dihydrocortisol-3 alpha-oxidoreductase(s)

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12 December 2020

Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence

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12 December 2020

Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9)

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12 December 2020

10.1016/J.STEROIDS.2011.01.003

Identifiers

DOI

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20 January 2020

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20 January 2020

PubMed publication ID

21255593

1 reference