Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels (Q34674336)

3 August 2017

title

Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels (English)

1 reference

3 August 2017

1 reference

Ping Xie

1

1 reference

3 August 2017

Hongling Zhu

2

1 reference

3 August 2017

Lin Jia

3

1 reference

3 August 2017

Yinyan Ma

4

1 reference

3 August 2017

Weiqing Tang

5

1 reference

3 August 2017

Youlin Wang

6

1 reference

3 August 2017

Bingzhong Xue

7

1 reference

3 August 2017

Hang Shi

8

1 reference

3 August 2017

Liqing Yu

9

1 reference

3 August 2017

publication date

17 October 2014

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3 August 2017

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3 August 2017

volume

237

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3 August 2017

issue

2

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3 August 2017

page(s)

609-617

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describes a project that uses

3 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4262594/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine.

1 reference

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New insights into how the intestine can regulate lipid homeostasis and impact vascular disease: frontiers for new pharmaceutical therapies to lower cardiovascular disease risk

7 July 2018

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Effects of ezetimibe on atherosclerosis in preclinical models

7 July 2018

1 reference

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Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism

7 July 2018

1 reference

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Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis.

7 July 2018

1 reference

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Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1.

7 July 2018

1 reference

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Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice

7 July 2018

1 reference

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Extracellular loop C of NPC1L1 is important for binding to ezetimibe

7 July 2018

1 reference

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Intestinal lipoprotein overproduction in insulin-resistant states

7 July 2018

1 reference

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Regulation of intestinal cholesterol absorption

7 July 2018

1 reference

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Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels

7 July 2018

1 reference

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Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake

7 July 2018

1 reference

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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

7 July 2018

1 reference

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

7 July 2018

1 reference

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Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

7 July 2018

1 reference

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

7 July 2018

1 reference

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Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

7 July 2018

1 reference

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Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

7 July 2018

1 reference

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Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis

7 July 2018

1 reference

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Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.

7 July 2018

1 reference

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Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins

7 July 2018

1 reference

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Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans.

7 July 2018

1 reference

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Absorption and metabolism of dietary cholesterol

7 July 2018

1 reference

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Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice.

26 October 2018

1 reference

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The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin.

26 October 2018

1 reference

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Plasma cholesterol is hyperresponsive to statin in ABCG5/ABCG8 transgenic mice.

26 October 2018

1 reference

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Caveolin-1 is not required for murine intestinal cholesterol transport.

26 October 2018

1 reference

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Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Fatty acids differentially regulate hepatic cholesteryl ester formation and incorporation into lipoproteins in the liver of the mouse

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia

26 October 2018

1 reference

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Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity, and insulin resistance

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Effectiveness and tolerability of ezetimibe in patients with primary hypercholesterolemia: pooled analysis of two phase II studies

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Postprandial dyslipidemia in men with visceral obesity: an effect of reduced LDL receptor expression?

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Improved metabolic control reduces the number of postprandial apolipoprotein B-48-containing particles in type 2 diabetes.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Prevalence of coronary heart disease in the Framingham Offspring Study: role of lipoprotein cholesterols

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262594

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

26 October 2018

1 reference

12 December 2020

Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population

1 reference

12 December 2020

In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

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12 December 2020

A sensitive and convenient method for lipoprotein profile analysis of individual mouse plasma samples

1 reference

12 December 2020

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

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12 December 2020

Impaired postprandial metabolism of apolipoprotein B48-containing remnant particles in normolipidemic subjects with brittle type 1 diabetes

1 reference

12 December 2020

U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans

1 reference

12 December 2020

10.1016/J.ATHEROSCLEROSIS.2014.09.036

Identifiers

DOI

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3 August 2017

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3 August 2017

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