Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections (Q34680240)

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English	Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections	scientific article

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections (English)

1 reference

Europe PubMed Central

3 August 2017

sexual transmission

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HIV transmission

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sexually transmitted infection

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prevention of HIV/AIDS

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Pedro M Mesquita

object named as

Pedro M Mesquita

2

0 references

1

object named as

Betsy C Herold

1 reference

Europe PubMed Central

3 August 2017

author name string

Rebecca P Madan

3

1 reference

Europe PubMed Central

3 August 2017

Marla J Keller

4

1 reference

Europe PubMed Central

3 August 2017

publication date

12 December 2010

1 reference

Europe PubMed Central

3 August 2017

American Journal of Reproductive Immunology

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Europe PubMed Central

3 August 2017

65

1 reference

Europe PubMed Central

3 August 2017

3

1 reference

Europe PubMed Central

3 August 2017

325-333

1 reference

Europe PubMed Central

3 August 2017

PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Immune responses to HIV vaccines and potential impact on control of acute HIV-1 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Female genital tract secretions inhibit herpes simplex virus infection: correlation with soluble mucosal immune mediators and impact of hormonal contraception.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Ex vivo comparison of microbicide efficacies for preventing HIV-1 genomic integration in intraepithelial vaginal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Copy number variation of defensin genes and HIV infection in Brazilian children.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Safety analysis of the diaphragm in combination with lubricant or acidifying microbicide gels: effects on markers of inflammation and innate immunity in cervicovaginal fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Effectiveness of cellulose sulfate vaginal gel for the prevention of HIV infection: results of a Phase III trial in Nigeria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Herpes simplex virus downregulates secretory leukocyte protease inhibitor: a novel immune evasion mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Enhancement of HIV infection by cellulose sulfate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Anti-HIV activity mediated by natural killer and CD8+ cells after toll-like receptor 7/8 triggering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

SAVVY vaginal gel (C31G) for prevention of HIV infection: a randomized controlled trial in Nigeria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Antimicrobial polypeptides are key anti-HIV-1 effector molecules of cervicovaginal host defense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

SAVVY® (C31G) Gel for prevention of HIV infection in women: a phase 3, double-blind, randomized, placebo-controlled trial in Ghana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Semen-derived amyloid fibrils drastically enhance HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Seminal plasma reduces the effectiveness of topical polyanionic microbicides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

A comprehensive murine model to evaluate topical vaginal microbicides: mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Alpha-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Seminal plasma promotes the attraction of Langerhans cells via the secretion of CCL20 by vaginal epithelial cells: involvement in the sexual transmission of HIV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Guiding the vaginal microbicide trials with biomarkers of inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Alpha-defensins in the prevention of HIV transmission among breastfed infants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Human immunodeficiency virus type 1 stimulates the expression and production of secretory leukocyte protease inhibitor (SLPI) in oral epithelial cells: a role for SLPI in innate mucosal immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Topical microbicides for the prevention of genital herpes infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 Infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Activity of alpha- and theta-defensins against primary isolates of HIV-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

The role of sexually transmitted diseases in HIV transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Evolution of primate theta-defensins: a serpentine path to a sweet tooth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

The θ-Defensin, Retrocyclin, Inhibits HIV-1 Entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Discovery of five conserved beta -defensin gene clusters using a computational search strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Safety of multiple daily applications of COL-1492, a nonoxynol-9 vaginal gel, among female sex workers. COL-1492 Phase II Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

Secretory leucocyte protease inhibitor in the male genital tract: PSA-induced proteolytic processing in human semen and tissue localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058365

7 July 2018

HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0897.2010.00932.X

21 January 2018

PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0897.2010.00932.X

21 January 2018

Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0897.2010.00932.X

21 January 2018

Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0897.2010.00932.X

21 January 2018

Human alpha defensin in HIV-exposed but uninfected individuals.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0897.2010.00932.X

21 January 2018

Role of beta-defensin-1 polymorphisms in mother-to-child transmission of HIV-1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0897.2010.00932.X

21 January 2018

Are defensin beta 1 gene polymorphisms associated with HIV infection and virus replication?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0897.2010.00932.X

21 January 2018

Secretory leukocyte protease inhibitor in vaginal fluids and perinatal human immunodeficiency virus type 1 transmission

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0897.2010.00932.X

21 January 2018

Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0897.2010.00932.X

21 January 2018

Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21143689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concerns regarding a randomized study of the timing of antiretroviral therapy in zimbabweans with AIDS and acute cryptococcal meningitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21143689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity of non-clade B primary HIV-1 isolates to mildly acidic pH

1 reference

https://pubmed.ncbi.nlm.nih.gov/21143689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of proinflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21143689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rate at which human sperm are immobilized and killed by mild acidity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21143689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1600-0897.2010.00932.X

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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