TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease (Q34692945)

4 August 2017

TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease (English)

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4 August 2017

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Edward Rockenstein

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Eliezer Masliah

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4 August 2017

Andreas Bender

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4 August 2017

Paula Desplats

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4 August 2017

Brian Spencer

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Anthony Adame

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Matthias Elstner

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Christoph Laub

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Sarina Mueller

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Andrew O Koob

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Michael Mante

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Emily Pham

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Thomas Klopstock

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4 August 2017

language of work or name

English

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publication date

23 April 2013

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4 August 2017

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e62277

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Creative Commons Attribution 4.0 International

4 August 2017

start time

23 April 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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2 references

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3633917/fullTextXML

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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Interaction of α-synuclein with vesicles that mimic mitochondrial membranes

7 July 2018

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Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants

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An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease

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Differential effects of wild-type and A53T mutant isoform of alpha-synuclein on the mitochondrial proteome of differentiated SH-SY5Y cells

7 July 2018

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7 July 2018

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A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

7 July 2018

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

7 July 2018

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Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases

7 July 2018

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Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

7 July 2018

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Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

7 July 2018

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Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody

7 July 2018

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Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

7 July 2018

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Mitochondrial association of alpha-synuclein causes oxidative stress

7 July 2018

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Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

7 July 2018

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

7 July 2018

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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

7 July 2018

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

7 July 2018

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Mice lacking alpha-synuclein are resistant to mitochondrial toxins

7 July 2018

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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

7 July 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

7 July 2018

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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

7 July 2018

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7 July 2018

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7 July 2018

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Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

7 July 2018

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Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

7 July 2018

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Complex I, iron, and ferritin in Parkinson's disease substantia nigra

7 July 2018

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

7 July 2018

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Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein

7 July 2018

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Transcription of the mammalian mitochondrial genome

7 July 2018

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Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062277

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062277

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062277

Localization of alpha-synuclein to mitochondria within midbrain of mice

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062277

Nature of mitochondrial DNA deletions in substantia nigra neurons

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062277

Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3633917

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3633917

Mitochondrial complex I deficiency in Parkinson's disease

26 October 2018

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12 December 2020

MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

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12 December 2020

Localization of alpha-synuclein to identified fibers and synapses in the normal mouse brain

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12 December 2020

A multiplex real-time PCR method to detect and quantify mitochondrial DNA deletions in individual cells

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12 December 2020

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12 December 2020

10.1371/JOURNAL.PONE.0062277

Identifiers

DOI

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4 August 2017

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4 August 2017

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