Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells (Q34699713)

4 August 2017

Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells (English)

1 reference

Downstream of raf1 Dmel_CG15793

4 August 2017

0 references

1 reference

Ras GTPase activating protein 1 Dmel_CG6721

1 reference

Ras oncogene at 85D Dmel_CG9375

1 reference

PDGF- and VEGF-related factor 2 Dmel_CG13780

1 reference

author name string

Anan Ragab

1

1 reference

4 August 2017

Tina Buechling

2

1 reference

4 August 2017

Viola Gesellchen

3

1 reference

4 August 2017

Kerstin Spirohn

4

1 reference

4 August 2017

Anna-Lisa Boettcher

5

1 reference

4 August 2017

Michael Boutros

6

1 reference

4 August 2017

language of work or name

English

0 references

publication date

4 February 2011

1 reference

4 August 2017

1 reference

4 August 2017

30

1 reference

4 August 2017

6

1 reference

4 August 2017

1123-1136

1 reference

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

A quantitative RNAi screen for JNK modifiers identifies Pvr as a novel regulator of Drosophila immune signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Nature meets nurture: molecular genetics of gastric cancer.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Navigating the network: signaling cross-talk in hematopoietic cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Epithelial morphogenesis and intestinal cancer: new insights in signaling mechanisms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

The art and design of genetic screens: RNA interference.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Positive and negative regulation of the Drosophila immune response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

A model of bacterial intestinal infections in Drosophila melanogaster

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

The host defense of Drosophila melanogaster

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

An essential complementary role of NF-kappaB pathway to microbicidal oxidants in Drosophila gut immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

From gut homeostasis to cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Secretion of Wnt ligands requires Evi, a conserved transmembrane protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Evidence that stem cells reside in the adult Drosophila midgut epithelium.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Identification of JAK/STAT signalling components by genome-wide RNA interference.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

The PDGF/VEGF receptor controls blood cell survival in Drosophila

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Functional dissection of an innate immune response by a genome-wide RNAi screen

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Analysis of Ras-induced overproliferation in Drosophila hemocytes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

A new mathematical model for relative quantification in real-time RT-PCR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

A modular misexpression screen in Drosophila detecting tissue-specific phenotypes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

Insect immunity: developmental and inducible activity of the Drosophila diptericin promoter

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061042

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

7 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Developmental control of blood cell migration by the Drosophila VEGF pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Guidance of cell migration by the Drosophila PDGF/VEGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Relish, a central factor in the control of humoral but not cellular immunity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

The Drosophila lymph gland as a developmental model of hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Pirk is a negative regulator of the Drosophila Imd pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

The adult Drosophila posterior midgut is maintained by pluripotent stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Functional analysis of the Drosophila immune response during aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Role of Drosophila IKK gamma in a toll-independent antibacterial immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Infection-induced proteolysis of PGRP-LC controls the IMD activation and melanization cascades in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Immunity regulatory DNAs share common organizational features in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Aging of the innate immune response in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.4

21 January 2018

Identifiers

DOI

10.1038/EMBOJ.2011.4

1 reference

4 August 2017

1 reference

4 August 2017

1 reference