Aconitase causes iron toxicity in Drosophila pink1 mutants (Q34699834)

4 August 2017

Aconitase causes iron toxicity in Drosophila pink1 mutants (English)

1 reference

Mitochondrial aconitase 1 Dmel_CG9244

4 August 2017

0 references

1 reference

GOA release 2020-03-11

Patrik Verstreken

8

0 references

author name string

Giovanni Esposito

1

1 reference

4 August 2017

Melissa Vos

2

1 reference

4 August 2017

Sven Vilain

3

1 reference

4 August 2017

Jef Swerts

4

1 reference

4 August 2017

Jorge De Sousa Valadas

5

1 reference

4 August 2017

Stefanie Van Meensel

6

1 reference

4 August 2017

Onno Schaap

7

1 reference

4 August 2017

25 April 2013

1 reference

4 August 2017

1 reference

4 August 2017

9

1 reference

4 August 2017

4

1 reference

4 August 2017

e1003478

1 reference

Creative Commons Attribution 4.0 International

4 August 2017

start time

25 April 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3636082/fullTextXML

inferred from PubMed Central ID database lookup

cites work

PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity

1 reference

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PINK1- and Parkin-mediated mitophagy at a glance

7 July 2018

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Silent information regulator 2 (Sir2) and Forkhead box O (FOXO) complement mitochondrial dysfunction and dopaminergic neuron loss in Drosophila PTEN-induced kinase 1 (PINK1) null mutant

7 July 2018

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The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants

7 July 2018

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Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder

7 July 2018

1 reference

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Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission

7 July 2018

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The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

7 July 2018

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Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12)

7 July 2018

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Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins

7 July 2018

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The interplay between mitochondrial dynamics and mitophagy

7 July 2018

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The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

7 July 2018

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Genetic animal models of Parkinson's disease

7 July 2018

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Mitochondrial iron metabolism and its role in neurodegeneration.

7 July 2018

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Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

7 July 2018

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The roles of PINK1 and Parkin in Parkinson's disease.

7 July 2018

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

7 July 2018

1 reference

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

7 July 2018

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Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

7 July 2018

1 reference

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Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures

7 July 2018

1 reference

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Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling

7 July 2018

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A highly reproducible rotenone model of Parkinson's disease

7 July 2018

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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

7 July 2018

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Iron, the substantia nigra and related neurological disorders

7 July 2018

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

7 July 2018

1 reference

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

7 July 2018

1 reference

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The PINK1/Parkin pathway regulates mitochondrial morphology

7 July 2018

1 reference

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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

7 July 2018

1 reference

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An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases

7 July 2018

1 reference

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Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to mitochondrial permeability transition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster.

7 July 2018

1 reference

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

7 July 2018

1 reference

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

7 July 2018

1 reference

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

7 July 2018

1 reference

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Characterization of mitochondrial ferritin in Drosophila

7 July 2018

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Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

7 July 2018

1 reference

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Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

7 July 2018

1 reference

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The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Molecular Pathways of Neurodegeneration in Parkinson's Disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Parkinson's disease: mechanisms and models

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Mitochondrial permeability transition induced by 1-hydroxyethyl radical

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Superoxide production by the mitochondrial respiratory chain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Aconitase, a two-faced protein: enzyme and iron regulatory factor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Normal mitochondrial genome in brain from patients with Parkinson's disease and complex I defect

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Superoxide sensitivity of the Escherichia coli aconitase.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Crystal structures of aconitase with isocitrate and nitroisocitrate bound

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003478

Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003478

The role of reactive oxygen species in mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003478

Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003478

Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003478

Dopamine-derived dopaminochrome promotes H(2)O(2) release at mitochondrial complex I: stimulation by rotenone, control by Ca(2+), and relevance to Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003478

A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003478

The inactivation of Fe-S cluster containing hydro-lyases by superoxide.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636082

Mitochondrial aconitase is a source of hydroxyl radical. An electron spin resonance investigation

26 October 2018

1 reference

12 December 2020

Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical

1 reference

12 December 2020

The role of O2.- in the production of HO.: in vitro and in vivo

1 reference

12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1003478

Identifiers

DOI

1 reference

4 August 2017

1 reference

4 August 2017

1 reference