Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins. (Q34701006)

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English	Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.	scientific article

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scholarly article

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30 August 2019

Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins (English)

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30 August 2019

GPI-anchor transamidase subunit 8 (GPI8), putative

1 reference

5 February 2019

GPI-anchor transamidase subunit 8 (GPI8), putative

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GPI-anchor transamidase subunit 8 (GPI8), putative

0 references

GPI-anchor transamidase subunit 8 (GPI8), putative

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Leishmania mexicana

object named as

Leishmania mexicana

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based on heuristic

inferred from title

Jeremy C. Mottram

5

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30 August 2019

author name string

J D Hilley

1

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30 August 2019

J L Zawadzki

2

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30 August 2019

M J McConville

3

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30 August 2019

G H Coombs

4

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30 August 2019

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1 April 2000

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30 August 2019

Molecular Biology of the Cell

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30 August 2019

11

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30 August 2019

4

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30 August 2019

1183-1195

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30 August 2019

Recent developments in the cell biology and biochemistry of glycosylphosphatidylinositol lipids (review).

1 reference

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7 July 2018

Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei.

1 reference

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7 July 2018

The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research.

1 reference

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7 July 2018

Glycosylphosphatidylinositol biosynthetic enzymes are localized to a stable tubular subcompartment of the endoplasmic reticulum in Leishmania mexicana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Biosynthesis of glycosylphosphatidylinositols in mammals and unicellular microbes.

1 reference

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7 July 2018

Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.

1 reference

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7 July 2018

Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins

1 reference

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7 July 2018

Parasite and mammalian GPI biosynthetic pathways can be distinguished using synthetic substrate analogues

1 reference

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7 July 2018

The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe

1 reference

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7 July 2018

Yeast Gpi8p is essential for GPI anchor attachment onto proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

COOH-terminal processing of nascent polypeptides by the glycosylphosphatidylinositol transamidase in the presence of hydrazine is governed by the same parameters as glycosylphosphatidylinositol addition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

The Leishmania promastigote surface antigen 2 complex is differentially expressed during the parasite life cycle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Requirements for glycosylphosphatidylinositol attachment are similar but not identical in mammalian cells and parasitic protozoa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Cleavage without anchor addition accompanies the processing of a nascent protein to its glycosylphosphatidylinositol-anchored form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

The role of inositol acylation and inositol deacylation in GPI biosynthesis in Trypanosoma brucei.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

How glycosylphosphatidylinositol-anchored membrane proteins are made

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

The promastigote surface protease (gp63) of Leishmania is expressed but differentially processed and localized in the amastigote stage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

The PSA-2 glycoprotein complex of Leishmania major is a glycosylphosphatidylinositol-linked promastigote surface antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Analysis of the signal for attachment of a glycophospholipid membrane anchor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Molecular cloning and characterization of the immunologically protective surface glycoprotein GP46/M-2 of Leishmania amazonensis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

The major surface glycoprotein (GP63) is present in both life stages of Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Transfer of glycosyl-phosphatidylinositol membrane anchors to polypeptide acceptors in a cell-free system

1 reference

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7 July 2018

The interaction of Leishmania species with macrophages

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

7 July 2018

A novel glycosylphosphatidylinositol in African trypanosomes. A possible catabolic intermediate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

26 October 2018

Targeted gene deletion of Leishmania major genes encoding developmental stage-specific leishmanolysin (GP63).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

26 October 2018

Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

26 October 2018

The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

26 October 2018

Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glycoprotein 63 in promastigotes and amastigotes of Leishmania mexicana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

26 October 2018

A novel CDC2-related protein kinase from Leishmania mexicana, LmmCRK1, is post-translationally regulated during the life cycle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

26 October 2018

Rapid isolation of DNA from trypanosomatid protozoa using a simple 'mini-prep' procedure.

1 reference

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26 October 2018

The glycoinositol phospholipids of Leishmania mexicana promastigotes. Evidence for the presence of three distinct pathways of glycolipid biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14840

9 December 2018

Genes encoding the major surface glycoprotein in Leishmania are tandemly linked at a single chromosomal locus and are constitutively transcribed

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of the green fluorescent protein as a marker in transfected Leishmania

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delineation of three pathways of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana. Precursors from different pathways are assembled on distinct pools of phosphatidylinositol and undergo fatty acid remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glycoinositolphospholipids from Leishmania panamensis contain unusual glycan and lipid moieties

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of free GPIs in amastigotes of Leishmania

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cell-free assay for glycosylphosphatidylinositol anchoring in African trypanosomes. Demonstration of a transamidation reaction mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lysosomal gp63-related protein in Leishmania mexicana amastigotes is a soluble metalloproteinase with an acidic pH optimum

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Legumain: asparaginyl endopeptidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An active carbonyl formed during glycosylphosphatidylinositol addition to a protein is evidence of catalysis by a transamidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63). The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phosphatidylinositol addition sites on N-terminal end cleavage, intracellul

1 reference

https://pubmed.ncbi.nlm.nih.gov/10749923

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1091/MBC.11.4.1183

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10749923%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

1 reference

Europe PubMed Central

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30 August 2019

1 reference

Europe PubMed Central

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30 August 2019

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