Pharmacokinetic and pharmacodynamic modeling of exendin-4 in type 2 diabetic Goto-Kakizaki rats (Q34702329)

4 August 2017

title

Pharmacokinetic and pharmacodynamic modeling of exendin-4 in type 2 diabetic Goto-Kakizaki rats (English)

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4 August 2017

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2

William J Jusko

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4 August 2017

Wei Gao

1

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4 August 2017

language of work or name

English

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publication date

14 December 2010

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Journal of Pharmacology and Experimental Therapeutics

4 August 2017

published in

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4 August 2017

volume

336

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4 August 2017

issue

3

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4 August 2017

page(s)

881-890

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Mechanism-based disease progression modeling of type 2 diabetes in Goto-Kakizaki rats

4 August 2017

cites work

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7 July 2018

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Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents.

7 July 2018

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Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats.

26 October 2018

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26 October 2018

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26 October 2018

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26 October 2018

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26 October 2018

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Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique

26 October 2018

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TIRF imaging of docking and fusion of single insulin granule motion in primary rat pancreatic beta-cells: different behaviour of granule motion between normal and Goto-Kakizaki diabetic rat beta-cells

26 October 2018

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Long-term renal changes in the Goto-Kakizaki rat, a model of lean type 2 diabetes

26 October 2018

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26 October 2018

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Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro

26 October 2018

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Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem.

26 October 2018

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Characterization of human and rat glucagon-like peptide-1 receptors in the neurointermediate lobe: lack of coupling to either stimulation or inhibition of adenylyl cyclase

26 October 2018

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12 December 2020

Late onset of diabetic nephropathy in spontaneously diabetic GK rats

1 reference

12 December 2020

Development of diabetes in the non-obese NIDDM rat (GK rat)

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12 December 2020

Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary

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12 December 2020

Precursor-dependent indirect pharmacodynamic response model for tolerance and rebound phenomena

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12 December 2020

Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations

1 reference

12 December 2020

Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats

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12 December 2020

Identifiers

DOI

10.1124/JPET.110.175752

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4 August 2017

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4 August 2017

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