Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease (Q34714277)

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English	Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease	scientific article

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scholarly article

1 reference

4 August 2017

Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease (English)

1 reference

4 August 2017

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author name string

Kelly A Meulendyke

1

1 reference

4 August 2017

Suzanne E Queen

2

1 reference

4 August 2017

Elizabeth L Engle

3

1 reference

4 August 2017

Erin N Shirk

4

1 reference

4 August 2017

Jiayang Liu

5

1 reference

4 August 2017

Joseph P Steiner

6

1 reference

4 August 2017

Avindra Nath

7

1 reference

4 August 2017

Patrick M Tarwater

8

1 reference

4 August 2017

David R Graham

9

1 reference

4 August 2017

Joseph L Mankowski

10

1 reference

4 August 2017

M Christine Zink

11

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4 August 2017

publication date

17 September 2014

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4 August 2017

Journal of NeuroVirology

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4 August 2017

20

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4 August 2017

591-602

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4 August 2017

6

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4 August 2017

describes a project that uses

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4267991/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

https://scigraph.springernature.com/pub.10.1007/s13365-014-0283-1

0 references

Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.

1 reference

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Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats

1 reference

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How Might We Cure HIV?

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Fluoxetine pretreatment promotes neuronal survival and maturation after auditory fear conditioning in the rat amygdala

1 reference

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Biomarker evidence of axonal injury in neuroasymptomatic HIV-1 patients

1 reference

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Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system

1 reference

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Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of down syndrome

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Targeting the glutamatergic system for the treatment of HIV-associated neurocognitive disorders

1 reference

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Targeting HIV latency: pharmacologic strategies toward eradication

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Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects

1 reference

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Catechins protect neurons against mitochondrial toxins and HIV proteins via activation of the BDNF pathway

1 reference

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CaMKII regulation in information processing and storage

1 reference

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1 reference

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Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease

1 reference

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7 July 2018

Fluoxetine protects neurons against microglial activation-mediated neurotoxicity

1 reference

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Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease

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HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

1 reference

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Selective serotonin reuptake inhibitor suppression of HIV infectivity and replication.

1 reference

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Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection

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Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA

1 reference

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HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities

1 reference

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7 July 2018

HIV and SIV induce alterations in CNS CaMKII expression and activation: a potential mechanism for cognitive impairment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267991

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The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus-associated neurological disease: from mechanism to treatment

1 reference

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Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT(1A) receptors

1 reference

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Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system

1 reference

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The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model

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Updated research nosology for HIV-associated neurocognitive disorders

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CSF neurofilament protein (NFL) -- a marker of active HIV-related neurodegeneration.

1 reference

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Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267991

7 July 2018

Dementia and neurocognitive disorders due to HIV-1 infection

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267991

7 July 2018

Oxidative stress and therapeutic approaches in HIV dementia

1 reference

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The neuropathogenesis of AIDS

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7 July 2018

Elevated neurofilament levels in neurological diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267991

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Searching for clues: tracking the pathogenesis of human immunodeficiency virus central nervous system disease by use of an accelerated, consistent simian immunodeficiency virus macaque model

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Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains

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Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory

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High viral load in the cerebrospinal fluid and brain correlates with severity of simian immunodeficiency virus encephalitis.

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7 July 2018

Accumulation of beta-amyloid precursor protein in HIV encephalitis: relationship with neuropsychological abnormalities.

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7 July 2018

5-Hydroxytryptamine deficits in the caudate nucleus in AIDS.

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7 July 2018

Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267991

7 July 2018

Fluconazole penetration in cerebral parenchyma in humans at steady state

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7 July 2018

Frontal cortex indoleamine-2,3-dioxygenase activity is increased in HIV-1-associated dementia

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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7 July 2018

Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell.

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21 January 2018

Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease

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https://api.crossref.org/works/10.1007%2FS13365-014-0283-1

21 January 2018

Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation.

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21 January 2018

The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection

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Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia

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21 January 2018

The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system

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21 January 2018

Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect

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21 January 2018

Cerebrospinal fluid markers that predict SIV CNS disease.

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21 January 2018

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

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https://api.crossref.org/works/10.1007%2FS13365-014-0283-1

21 January 2018

Patients with Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases Have Increased Levels of Neurofilament Protein in CSF

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https://api.crossref.org/works/10.1007%2FS13365-014-0283-1

21 January 2018

MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters.

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https://api.crossref.org/works/10.1007%2FS13365-014-0283-1

21 January 2018

Central nervous system correlates of behavioral deficits following simian immunodeficiency virus infection

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https://api.crossref.org/works/10.1007%2FS13365-014-0283-1

21 January 2018

Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis

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21 January 2018

Cognitive dysfunction in HIV patients despite long-standing suppression of viremia

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9 December 2018

Accumulation of beta-amyloid precursor protein in axons correlates with CNS expression of SIV gp41

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12 December 2020

based on heuristic

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Brain kinetics of paroxetine and fluoxetine on the third day of placebo substitution: a fluorine MRS study

1 reference

https://pubmed.ncbi.nlm.nih.gov/25227932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S13365-014-0283-1

1 reference

4 August 2017

1 reference

4 August 2017

1 reference

4 August 2017

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