Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus (Q34725095)

4 August 2017

title

Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus (English)

1 reference

4 August 2017

main subject

Staphylococcus aureus

1 reference

Dilek Ince

1

1 reference

4 August 2017

Xiamei Zhang

series ordinal

2

1 reference

4 August 2017

L Christine Silver

series ordinal

3

1 reference

4 August 2017

David C Hooper

series ordinal

4

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4 August 2017

language of work or name

English

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publication date

1 January 2003

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Antimicrobial Agents and Chemotherapy

4 August 2017

published in

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4 August 2017

volume

47

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4 August 2017

issue

1

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4 August 2017

page(s)

274-282

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Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone

4 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions

7 July 2018

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Potent antipneumococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Activity of gemifloxacin against penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae displaying topoisomerase- and efflux-mediated resistance mechanisms

7 July 2018

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Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Inducible NorA-mediated multidrug resistance in Staphylococcus aureus

7 July 2018

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Structure and mechanism of DNA topoisomerase II

7 July 2018

1 reference

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A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome

7 July 2018

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Confirmation of protoplast fusion-derived linkages in Staphylococcus aureus by transformation with protoplast DNA.

7 July 2018

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Genetic systems in staphylococci

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

Comparative in vitro potency of gemifloxacin and fluoroquinolones against recent European clinical isolates from a global surveillance study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

Comparative in vitro activities of five quinolone antibiotics, including gemifloxacin, against clinical isolates

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

Comparative in vitro activity of gemifloxacin against gram-positive and gram-negative clinical isolates in Argentina

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

Comparative in vitro activity of gemifloxacin, ciprofloxacin, levofloxacin and ofloxacin in a North American surveillance study

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

gyrB-225, a mutation of DNA gyrase that compensates for topoisomerase I deficiency: investigation of its low activity and quinolone hypersensitivity

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

Comparative in vitro activity of gemifloxacin

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance.

26 October 2018

1 reference

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Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149033

In vitro activity of gemifloxacin and five other fluoroquinolones against defined isogenic mutants of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus

26 October 2018

1 reference

12 December 2020

Evaluation of gemifloxacin (SB-265805, LB20304a): in vitro activity against over 6000 gram-positive pathogens from diverse geographic areas

1 reference

12 December 2020

In vitro activity of gemifloxacin against a broad range of recent clinical isolates from the USA

1 reference

12 December 2020

Mechanisms of fluoroquinolone resistance

1 reference

12 December 2020

10.1128/AAC.47.1.274-282.2003

Identifiers

DOI

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4 August 2017

1 reference

4 August 2017

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